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Surgical (anatomical) pathology and/or research technique learning experiences for foreign medical students.
Japan (IFMSA-Japan) - Kurume University, Kurume
Department of Pathology
Hirohisa Yano, M.D., Ph.D.
Jun Akiba, M.D., Ph.D. Sachiko Ogasawara, Ph.D. ReiichiroKondo , M.D., Ph.D. Hironori Kusano, M.D., Ph.D.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
We engage in pathological diagnosis of biopsy, surgical, and autopsy materials obtained in Kurume University Hospital and affiliated hospitals, and pathological research of many different fields. Liver pathology is the main field to study, and pathomorphologic studies of hepatocellular carcinoma (HCC), non-neoplastic hepatic nodular lesions, hepatitis, and pediatric hepatic disorders are performed. We also specialize in experimental and molecular pathologic studies of HCC by using liver cancer cell lines and patient HCC tissues, and immunohistochemical, molecular and biochemical techniques. We are interested in cancer stem cell and histogenesis of liver cancer, and establishment of new molecular targeted therapy of HCC. We have colleagues conducting pathological research on gastrointestinal tracts, bile duct, pancreas, female genital organs, breast, urinary tracts, and so forth.
What is the aim of the project?
The applicant(s) of the project can learn (1) the processes of pathological diagnosis of a variety of neoplastic and non-neoplastic diseases (from pathological specimen preparation to microscopic observation); (2) pathological characteristics of specific diseases (e.g., HCC); (3) theory, application, technique, and result interpretation of immunohistochemical staining; and (4) biochemical and molecular biology techniques (e.g., tissue culture, RNA(Ribonucleic acid), DNA(Deoxyribonucleic acid) and protein extraction, Immunoblotting, polymerase chain reaction, and so forth).
What techniques and methods are used?
Biochemical and molecular biology techniques (e.g., tissue culture, RNA, DNA and protein extraction, Immunoblotting, polymerase chain reaction, and so forth).
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
At first, the studentsshould learn the basic procedure to prepare hematoxylin&eosin- stained sectionsand knowledge for pathological diagnosis as a pathology trainee. Then, they observe and learn techniques (e.g., immunohistochemical staining, polymerase chain reaction, tissue culture, etc.) necessary for pathological diagnosis and research under supervision from our professors. Finally, theyhave to understand and master all techniques by themselves.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Process of pathological diagnosis, pathological characteristics of specific diseases, immunohistochemistry, tissue culture, biochemical and molecular techniques (PCR, immunoblotting, and etc.).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Nomura Y; Nakashima O; Akiba J; Ogasawara S; Fukutomi S; Yamaguchi R; Kusano H; Kage M; Okuda K and Yano H: Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver. J ClinPathol; 2016.
- Nakayama M; Ogasawara S; Akiba J; Ueda K; Koura K; Todoroki K; Kinoshita H and Yano H: Side population cell fractions from hepatocellular carcinoma cell lines increased with tumor dedifferentiation; but lack characteristic features of cancer stem cells. J GastroenterolHepatol 29: 1092-1101; 2014.
- Akiba J; Nakashima O; Hattori S; Tanikawa K; Takenaka M; Nakayama M; Kondo R; Nomura Y; Koura K; Ueda K; Sanada S; Naito Y; Yamaguchi R and Yano H: Clinicopathologic analysis of combined hepatocellular-cholangiocarcinoma according to the latest WHO classification. Am J SurgPathol 37: 496-505; 2013.
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