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Complex analysis of hemostasis and fibrinolysis in cancer patients
Bulgaria (AMSB) - Medical University of Plovdiv, Plovdiv
Prof. Zhanet Grudeva-Popova, MD, PhD
Elina Beleva, MD, PhD
English , German
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Malignant diseases arise and progress in dependence of alterations in tumor microenvironment and systemic homeostasis. These changes include deranged hemostatic system, which naturally functions as innate host defense mechanism assuring cell integrity and blood flow. Tumors induce hemostatic disbalance by several mechanisms: production and secretion of procoagulants, suppression of natural anticoagulants, endothelial activation with prothrombotic conversion and angiogenic switch. Cancer-induced hemostatic perturbations facilitate host tolerance and are beneficial for tumor growth, angiogenesis and metastasis. The relationship between hemostatic system and neoplasia is bi-directional. Several oncogenic pathways depend on the functional activity of hemostatic proteins, while their expression might be under the control of tumor-driven molecular events. The interdependence of cancer and hemostatic system justifies the concept that hemostatic components might be reliable biomarkers for disease activity and therapeutic efficacy. Clinical studies analyzing the predictive and prognostic potential of hemostatic factors are necessary in order to be established as surrogate biomarkers.
What is the aim of the project?
Characterizing derangements in hemostatic system and fibrinolysis induced by malignant state.
What techniques and methods are used?
Coagulometric tests for measurement of D-Dimer, vWF(Von Willebrand disease), АТ III(Antithrombin III); Immune-enzyme methods for analysis of Tissue factor, P-selectin, prothrombin fragments 1+2, thrombin-antithrombin complexes, tissue plasminogen activator
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Collect blood samples; coordinate sample analysis; “shadowing” execution of laboratory tests; take part in results analysis; literature review.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary introductory seminar in hemostasis: issues in cancer patients.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
None preliminary Subjects passed: Clinical laboratory / hemostasis Certificate of: English comprehension
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
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