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Role of macrophages in nervous system conditions
Catalonia (AECS) - Autonomous University of Barcelona (UAB) - Sciences Faculty, Barcelona
Department of Cellular Biology, Physiology and Immunology
Xavier Navarro Acebes
Ruben Lopez Vales
English (required), Spanish, Catalan
Type of Research Project
- Basic science
What is the background of the project?
Macrophages play an essential phagocytic role to protect the body from invasion by microorganisms such as bacteria and parasites. After injury or disease, macrophages clear dead and dying cells and help repair the tissue. However, under certain conditions macrophage activation can lead to secondary damage which is particularly detrimental in the central nervous system (CNS) because of the limited ability of CNS neurons to replenish themselves and of axons to regenerate. In other experimental conditions, activated macrophages in the CNS do not cause secondary injury. Understanding these differences will help in developing strategies to effectively modulate macrophage responses after spinal cord injury. The student will participate in a project focused on modulating the activation of macrophages after nervous system injury in order to promote tissue repair. Immunohistochemistry, flow cytometry, western blotting and real time Polymerase Chain Reaction.
What is the aim of the project?
The student will participate in a project focused on modulating the activation of macrophages after nervous system injury in order to promote tissue repair.
What techniques and methods are used?
Immunohistochemistry, flow cytometry, western blotting and real time Polymerase Chain Reaction.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will assist to weekly seminars provided by the members of the laboratory and will help in project leaded by other members of the laboratory. If the student obtains critical results of the project he/she will be a co-author of the work, if it is published.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous expertise in the neuroinflammation field is recommended.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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