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Prevalence of Non-alcoholic fatty liver diseases (NAFLD) and it’s complications among employees at Banha University hospital.
Egypt (IFMSA-Egypt) - Benha Faculty of medicine, Benha
Hepatology, Gastroenterology and infectious diseases department, Benha university hospital, Benha , Egypt
Prof. Mustafa Soliman El-kady
Prof.Reda Muhamed El-Badawy - Dr. Abeer Mahmoud Muhamed
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The prevalence of non-alcoholic fatty liver (NAFLD) in all age groups has increased since the late 1980s to become one of the most common causes of chronic liver diseases after HCV. An emerging concern is the apparent onset of significant NAFLD and non-alcoholic steatohepatitis (NASH) in early life, thereby planting the roots of chronic diseases. - Both NAFLD and non-alcoholic steatohepatitis (NASH) are strongly linked to obesity, type 2 diabetes mellitus, and metabolic syndrome. Epidemiologic studies reported that persons with NAFLD are more likely to die from cardiovascular disease than from liver-related complications. This risk seems to be proportional to the amount of fat in the liver and is independent of the presence of non-alcoholic steatohepatitis (NASH).
What is the aim of the project?
Evaluate the prevlance of NAFLD and its complications among employee at Benha Univesity hospital. - Use of fatty acid binding protien1 (FABP1) as non invasive diagonostic marker and assessment of it's predictive and prognostic value in NAFLD and its complications.
What techniques and methods are used?
This will be a prospective cross sectional study at Benha University hospital for employees from 18-60 years old. Subjects will be evaluated clinically by abdominal examination, measuring blood pressure and physically by calculating body mass index (BMI) heigh/weight. - Investigation as follow : complete blood count (CBC), fasting blood sugar, glycated heamoglobin (HbA1c) , liver function tests, lipid profile and serum insulin.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Data collection: collecting medical history from subjects (all people from age 18 to 60 years old both males and females, from Benha university employees and students). (Student could do it himself ) - Clinical evaluation of subjects: measuring blood pressure. (Under supervision of the tutor) - Physical evaluation of subjects : measuring body mass index (BMI) = heigh/weigh ². (Under supervision of the tutor) - Statistical analysis of the results: The collected data will be tabulated and analyzed using SPSS version 16 soft ware. ( student could do it himself )
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be lectures and seminars provided by the tutor about 'fatty liver and it's complications mainly cardiovascular ones.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
To be oriented about the basics of statistical analysis Is there any special knowledge or a certain level of studies needed? Subjects passed: - Physiology - Pathology - Pharmacology - Microbiology - Histology - Biochemistry - Anatomy
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Xu A et al. Circulation. (2007) DOI: 10.1161/CIRCULATIONAHA.106.647503
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