Projects
Name
Pesticides and other environmental chemical agents: do they cause pancreatic cancer?
University
Catalonia (AECS) - University Pompeu Fabra (UPF) - Campus Universitari Mar, Barcelona
Domain
Epidemiology
Departement
Clinical and Molecular Epidemiology of Cancer research Group
Head
Dr. Miquel Porta
Tutor
Dr. Miquel Porta, Jose Pumarega, Magda Gasull, Natalia Pallares
Languages
English (required) and Spanish (accepted)
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
yes yes yes yes yes yes yes No yes yes yes yes
Type of Research Project
- Basic science
What is the background of the project?
This project is divided in two sections: the projects PANKRAS I and PANKRAS II, which we develop in collaboration with the Cellular and Molecular Biology Unit and other organizations such as CSIC, Miguel Hernandez of Elx University, the International Agency for Research on Cancer (IARC), the Finnish Institute of Occupational Health and the Harvard School of Public Health - Channing Laboratories. Cancer is a complex set of processes that result from the interaction of genetic, clinical and environmental factors, understanding environmental as the physical, cultural, economic and politic context. We think that that the studies about cancer molecular basis need to: Be spread beyond the lab into the clinical and demographic context, be assessed scientifically on whether they can be useful for clinical assistance, and be integrated into studies about cancer environmental causes in order to estimate their potential contribution to improve the effectiveness of prevention programs. The aim of the project is going to vary depending on the amount of work that we have when the student comes. However, our goal is to achieve an optimal integration of professional cultures, scientific knowledge, methodologies and techniques. The main objective of this project is to collect data from pancreatic cancer patients from hospital records and analyze it in order to find predisposing, enabling, precipitation and reinforcing epidemiological factors. The student is going to use epidemiological techniques as well as some basic biostatistics and genetic methods. Some examples of epidemiological techniques are the measurement of occurrence and association, calculating the incidence and cumulative rates, the cumulative incidence, the risk, rate, odds and hazard ratios as well as the absolute risk reduction and the attributable risk.
What is the aim of the project?
The aim of the project is going to vary depending on the amount of work that we have when the student comes. However, our goal is to achieve an optimal integration of professional cultures, scientific knowledge, methodologies and techniques. Our research experience is quite transdisciplinar and we think that we are one of the Spanish pioneer groups in clinical and molecular epidemiology. This is why uncovering the causes of pancreatic cancer may be the most ambitious goal in cancer research both from the biological and public health point of view.
What techniques and methods are used?
The student is going to use epidemiological techniques as well as some basic biostatistics and genetic methods.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will help the researchers develop the project and he/she is expected to dedicate a minimum of 6h a day to participate in the aquisition of data and posterior statistical analysis in a database. At first he/she will be expected to read the literature and then contribute to the progression of the study by obtaining and analysing data using the methods explained above. As a final outcome, a final report summarizing all the activities undertaken during the stay is required and he/she will be involved in the presentation of reports and the writing of a scientific paper if the project comes to that.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
He/she has previous knowledge on statistical analysis techniques. Subjects passed: Epidemiology. Previous experience with: Statistical software (SPSS, R,...).
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields
Articles
- http://jech.bmj.com/content/68/7/592.long
- https://www.ncbi.nlm.nih.gov/pubmed/?term=-+Larrea-Killinger+C%2C+Mu%C3%B1oz+A%2C+Mascar%C3%B3+J%2C+Zafra+E%2C+Porta+M.+Discourses+on+the+Toxic+Effects+on+Internal+Chemical+Contamination+in+Catalonia%2C+Spain.+Med+Anthropol
- https://www.ncbi.nlm.nih.gov/pubmed/27863813