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Investigation of inhibition effect of tumor spheroids under alternating electric field
Taiwan (FMS-Taiwan) - Chang Gung University, Taipei
Graduate Institute of Medical Mechatronics
Kin Fong Lei
Type of Research Project
- Basic science
What is the background of the project?
Description: In cancer treatment, such as surgery, chemotherapy, radiation therapy, targeted therapy, and many others, the thought of having them frightens many cancer patients because they are invasive therapy or induce serious side effects. In 2004, a new cancer treatment of using alternating electric fields (called tumor treating fields, abbreviated as TTFields) was proposed and is associated with non-invasion, minimal toxicity, and better quality of life. In this project, a microfluidic three dimensional (3D) cell culture device incorporating with stimulating electrodes is developed to investigate the inhibition effect of tumor spheroids under the application of TTFields. These results provide foundation of the development of effective therapeutic strategies.
What is the aim of the project?
Aim:In vitro study of the inhibition effect of tumor spheroids under the application of alternating electric field.
What techniques and methods are used?
Used Techniques:Students should know cell culture technique and bio-assays for quantifying cell viability. Cell culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. Cell culture conditions can vary for each cell type, but artificial environments consist of a suitable vessel with substrate or medium that supplies the essential nutrients (amino acids, carbohydrates, vitamins, minerals), growth factors, hormones, and gases (CO2, O2), and regulates the physio- chemical environment (pH buffer, osmotic pressure, temperature).Bioassay (commonly used shorthand for biological assay or assessment), or biological standardization is a type of scientific experiment. A bioassay involves the use of live animal or plant (in vivo) or tissue or cell (in vitro) to determine the biological activity of a substance, such as a hormone or drug. Bioassays are typically conducted to measure the effects of a substance on a living organism and are essential in the development of new drugs and in monitoring environmental pollutants.
What is the role of the student?
- The tasks will be done under supervision
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
During the stay, students are required to perform experiments including cell culture and bio-assays by their own. Also, experimental results should be analyzed and made them presentable. Communication is as important as any technical task. While doing any experiment, make sure that everything is understood and your partners or coworkers are well informed.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, students will be instructed by lab assistants.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous experience with cell culture The basic cell culture skills are required; however, students are encouraged to learn during this exchange program. A scientific report is demanded after the exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- E.D. Kirson; Z. Gurvich; R. Schneiderman; E. Dekel; A. Itzhaki; et al.; Disruption of cancer cell replication by alternating electric fields. Cancer Res 64; 3288-3295; 2004
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