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Signaling crosstalk in skin stem cells
Belgium (BeMSA) - Université Catholique de Louvain, Brussels
de Duve Institute, Université catholique de Louvain, Avenue Hippocrate 74, B1.74.09, B-1200 Brussels, Belgium
Anthony Veltri, Christopher Lang
Type of Research Project
- Basic science
What is the background of the project?
Tissue homeostasis and regeneration require a precise balance between quiescence and activation of adult stem cells. We use skin as a model system to study the behaviors of adult stem cells and dissect the underlying mechanisms regulating stem cell function and tumorigenesis.
What is the aim of the project?
The main interest of our lab is to understand the molecular and cellular mechanisms that regulate the balance between quiescence and activation of adult stem cells, as well as their contribution to skin tumorigenesis.
What techniques and methods are used?
1. Mouse genetics: handling mouse lines, breeding, genotyping etc. 2. Cell culture: culturing cells, performing transfection or viral infection 3. Fluorescence microscopy: preparing skin tissues, sectioning, histological analyses, immunostaining etc.
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
If the student does not have any background or experiences on bench work before, he/she will mainly observe other lab members performing experiments and participate in the discussion with the supervisor or other lab members. Once the student is familiar with the basic techniques, he/she can perform basic experiments, e.g. DNA extraction or gel electrophoresis, under the supervision of others.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Recommended to read some research articles beforehand. During the intership, attending seminars is encouraged.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Experiences on basic bench work, e.g. pipetting. Subjects passed: Biology or associated courses
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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