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Microenvironment factors in the prognosis of prostate cancer
Croatia (CroMSIC) - University of Rijeka, Rijeka
Department of pathology
Nives Jonjić M.D., Ph.D.
Gordana Đorđević M.D., Ph.D.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Prostate cancer is the most common malignancy and the second most frequent cause of death among men. The choice of therapy according to the latest criteria of aggressiveness and risk recurrence based still on the classical clinicopathological factors. Recent research based on changes of the microenvironment and tumor infiltrating lymphocytes (TIL's) which can initiate progression of cancer. The remodeling of the extracellular matrix (ECM) and epithelial mesenchymal transition (EMT) starts with a reduced expression of adhesion molecules, increased expression of matrix metalloproteinases (MMPs), which is provoked especially by the action of chemokines, among others interleukin-8 (IL-8). Previous retrospective studies ECM changes in prostate cancer within the project "Molecular mechanisms of tumor expression and metastasis of breast cancer and prostate cancer" (062-0620095-0077), included the importance of tissue expression of MMP 2 and 9, CD44 and Ki67 molecules in prostate cancer prognosis. The study of molecular biomarkers p53, NFkB, bcl 2 contributed to the knowledge of the importance of the different expression of cell cycle regulators for the behavior of prostate cancer in the moment of radiotherapy. Planned continuation of this work should compare these molecules in different groups of patients in relation to the therapy. Planned continuation of this work should compare these molecules in different groups of patients in relation to the therapy. According to the risk guidelines for patients with localized disease, our prospective study is based on the expectation that the determination of IL-8 and MMP 9 in the serum could indicate a moment of tumor progression and the need for more aggressive therapies. We expect that the quantification and the characterization of TIL, along with clinical pathological parameters, could be used as a simple clinical index in predicting recurrence based on the immune response of the tumor. Our prospective study is based on the expectation that the determination of IL-8 and MMP 9 in the serum could indicate a moment of tumor progression and the need for more aggressive therapies. We expect that the quantification and the characterization of TIL, along with clinical pathological parameters, could be used as a simple clinical index in predicting recurrence based on the immune response of the tumor
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of laboratory work.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- "Molecular mechanisms of tumor expression and metastasis of breast cancer and prostate cancer" (062-0620095-0077)
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