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Effect of Atenolol as an enhancer for antimalarials on Plasmodium falciparum s infection - Double Randomized Clinical Trial Blind Controlled with Placebo
Universidade Federal do Amapa (UNIFAP)
Dept of Biological and Helth Sciences, Universidade Federal do Amapa, Rod. JK Km 02 s/n, 68903-419, Universidade, Macapa, AP, Brazil.
Marlucilena Pinheiro da Silva
Theory: Rosilene Ferreira Cardoso Research: Rosilene Ferreira Cardoso Fieldwork: Amanda Fernandes Medeiros
Type of Research Project
- Global Action Project (GAP)
What is the background of the project?
Malaria is a tropical disease of great relevance to public health due to high rates of morbidity and mortality worldwide. In Brazil, it is endemic in the Amazon region, where natural conditions are favorable for disease development.
What is the aim of the project?
The aim of this study is to compare the effect of atenolol as an enhancer to antimalarials in Plasmodium falciparum infection, check the time to eliminate the blade assessed by thick blood, and observe blocking the production of melatonin by the atenolol dosage levels 6 urinary – sulphatoxymelatonin.
What techniques and methods are used?
FIELDWORK: The student will follow up general care in patients with Malaria, to become familiar and to learn more about it before effectively dealing with the research’s patients . Location: Basic Health Units and Macapa's Emergency Hospital RESEARCH:The student will follow the care and evolution of Malaria patients participating in the project, but will also have contact with Malaria patient medical care outside the project, in order to know more about Malaria. He's task will be to receive the patients, to have the first conversation about the Consent Form and from there to follow the patient in the research, also to help in the collection and storage of samples. He can participate in all phases of the project.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student should be aware of the classes that will be offered to them about the disease related to the research, besides studying about it and seeking to be informed about the treatment scheme, among other aspects. He must also learn about the Brazilian information system and to interpret the data from it. He will also follow up visits to patients with malaria, so that he knows the logistics and the flow chart of the consultation, evolution and treatment. In addition, he will observe blade collection and learn about routine examinations that are necessary for diagnosis’ confirmation. He will assist in the conditioning / handling of the samples too.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures and courses.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
PREPARATION: The student will attend classes and seminars related to the proposed topic, and will also have training to know the Brazilian database before starting to act in the research itself. REQUIREMENTS: The student must know the disease in question and also the biosafety standards used within a hospital and the basic health units. He should also know how to work as a group.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Alves E; Bartlett PJ; Garcia CR; Thomas AP Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells. J Biol Chem; 286(7): 5905-12; 2011.
- Bagnaresi P; Alves E; da Silva HB; Epiphanio S; Mota MM; Garcia CR. Unlike the synchronous Plasmodium falciparum and P. chabaudi infection; the P. berghei and P. yoelii asynchronous infections are not affected by melatonin. Int J Gen Med; 2: 47-55; 2009.
- Beraldo FH; Almeida FM; da Silva AM; Garcia CR. Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle. J Cell Biol;170(4): 551-7; 2005 Aug 15.
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