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Modulation of gut microflora and lipid metabolism in the prevention of cardiovascular disease using probiotic microorganisms and omega-3 polyunsaturated fatty acids
University of Pavol Jozef Safarik
Institute of Experimental Medicine
Alojz Bomba DVM, DrSc.
Lubos AMBRO, MSc. PhD..
Type of Research Project
- Basic science
What is the background of the project?
Cardiovascular diseases are one of the most serious health issues of human medicine. Changes in composition of the gut microbiome may influence lipid absorption from the gastrointestinal tract associated with increased bacterial lipopolysaccharide transfer into the bloodstream and with increased risk of cardiovascular disease. By modulation of the gut microflora, one can influence metabolic and immunological function of the host, which is an important factor for prevention of various diseases. Therefore, we propose use of probiotic microorganisms and substances of natural origin in prevention of human cardiovascular disease. Moreover, a combination of synergistically acting substances of the natural origin is a possible way to increase the effectiveness of probiotics.
What is the aim of the project?
The main objective of the project is to gain new insights into the modulation of intestinal microflora and lipid metabolism utilizing probiotic microorganisms and omega-3 polyunsaturated fatty acids for preventing cardiovascular diseases.
What techniques and methods are used?
? The laboratory work will include various in vitro methods from microbiology and molecular biology: In vitro cultivation of the human gut microbiome; Bacterial DNA extraction ? preparation of the samples for further analysis; Polymerase chain reaction ? amplification of the bacterial DNA; Denaturant gradient gel electrophoresis ? bacterial community DNA fingerprinting
What is the role of the student?
What are the tasks expected to be accomplished by the student?
will to work in a lab
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
To have a desire to work in the laboratory.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Tzeneva VA1 Heilig HG; van Vliet WA; Akkermans AD; de Vos WM; Smidt H.:16S rRNA targeted DGGE fingerprinting of microbial communities. Methods Mol Biol. 2008;410:335-49.
- Ercolini D.: PCR-DGGE fingerprinting: novel strategies for detection of microbes in food. J Microbiol Methods. 2004 Mar;56(3):297-314.
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