Structural basis for increased bone fragility in aging
Serbia (IFMSA-Serbia) - University of Belgrade, Belgrade
Laboratory for
professor Marija Djuric
professor Marija Djuric
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes Yes Yes Yes No No No Yes Yes Yes Yes
Type of Research Project
- Basic science
What is the background of the project?
Bone fractures frequently occur in elderly persons even after low-energy trauma. Given that the young individuals would not sustain a fracture under such conditions, it is clear that the main cause of easy bone fracturing originates from the structural and compositional characteristics of aged bone itself. Observing bone from macro- to nano-levels shows us the complexity of bone hierarchical organization and reveals various determinants of bone strength. In particular, recent project focusing on bone at micro and nano-scale reveales distinctive features of the bone internal architecture and bone matrix that could provide additional explanation for increased bone fragility in advanced age, independent from age-related effects at macroscopic levels of bone hierarchical structure and only partly related to bone loss in aging.
What is the aim of the project?
The aim of the project is to investigate how bone microstructure leads to increased bone fragility.
What techniques and methods are used?
Preparation of bone specimens, micro-computed tomography (micro-CT) scanning of the bone specimens ex vivo, quantitative analysis of 3D bone scans, polarized light microcopy, image analysis, statistical analysis
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will perform search of scientific literature, undertake the preparation of specimens for microscopic analyses, and perform polarized light microcopy. The student will participate in quantitative analysis of three-dimensional bone scans made by micro-computed tomography under the supervision of laboratory staff, as well as in image analysis. The student will also participate in statistical analysis of data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
basic knowledge of bone anatomy and histology subjects passed: anatomy/histology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Students in biomedical fields