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Endocrine disrupting effects on the development of cardiovascular diseasescardiovascu
Portugal ( PorMSIC) - University Beira Interior, Covilha
Faculdade de Ciencias da Saude, Universidade da Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilha, Portugal
Prof. Doutor Taborda Barata
Maria Elisa Cairrao, Ignacio Verde
Type of Research Project
- Basic science
What is the background of the project?
Endocrine disruptor chemicals (EDCs) are released by the human activities and have the ability to mimic or antagonize the action of hormones, thus affecting the normal functioning of organisms leading to widespread effects in humans and wildlife. These chemicals are ubiquitous in the environment. Considering the amount of these compounds present in everyday modern life, namely in consumer products, humans are constantly exposed and, therefore, undoubtedly subjected to their deleterious effects. Growing evidence suggests that EDCs are involved in several cancer types, autoimmune diseases and allergies, infertility and malformations of newborn male genitalia, neurodevelopmental diseases, type 2 diabetes, obesity and cardiovascular diseases. The health costs associated with these diseases are considerable and a recent report disclosed that exposure to EDCs in the European Union may be costing up to 31 billion euros per year.
What is the aim of the project?
With this project we will investigate the contribution of these substances to develop CVD. In this sense, we will study three types of EDCs widespread in our environment and with high production volumes, namely bisphenol-A (BPA), phthalates and organotin compounds (OTs), all found in consumer products including medical materials
What techniques and methods are used?
Organ bath; Real Time Polymerase Chain Reaction (PCR), Planar cell surface area.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to understand the scientific question and to learn and help in the performance of the experiments, particularly in the techniques described above - Organ Bath; Real Time PCR, Planar cell surface area. Depending on the experience and understanding about the techniques the student will be able to perform those techniques alone.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, preliminary readings about the Endocrine disruptors.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Morgado M; Cairrao E; Santos-Silva AJ; Verde I. Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle. Cell Mol Life Sci. 2012;69(2):247-66.
- Feiteiro J; Verde I; Cairrao E. Cyclic guanosine monophosphate compartmentation in human vascular smooth muscle cells. Cell Signal. 2016. March 28 (3): 109?116.
- Saldanha PA; Cairrao E; Maia CM; Verde I. Long and Short Term Effects of Androgens in Human Umbilical Artery Smooth Muscle. Clin Exp Pharmacol Physiol. 2013 Mar;40(3):181-9.
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