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Preclinical investigation of novel anticancer drugs
Austria (AMSA) - University of Vienna, Vienna
Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna
Prof. Maria Sibilia
Ass. Prof. Petra Heffeter, Diana Groza, Sonja Hager
english or german
Type of Research Project
- Basic science
What is the background of the project?
We are working in an interdisciplinary research cooperation with synthetic chemistry with the aim to develop novel anticancer drugs with enhanced tumor-targeting properties. Anti-cancer drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy. Our aim should not only help to improve the tolerability of the novel drugs but also improve the treatment efficiency against multi-drug resistant malignancies. Aim of the project is the evaluation of a novel targeted drug against human cancer cells in cell culture (and upon interest, also in mouse models). The candidate will test the new drugs on diverse cancer cell lines from different tissue origin with diverse forms of drug resistance. This will then be further analyzed by diverse cell- and molecular biological methods (e.g. flow cytometry or Western blotting). Upon interest, we can also bioinformatically evaluate in silico array data.
What is the aim of the project?
Aim of the project is the evaluation of a novel targeted drug against human cancer cells in cell culture (and upon interest, also in mouse models)
What techniques and methods are used?
The candidate will test the new drugs on diverse cancer cell lines from different tissue origin with diverse forms of drug resistance. This will then be further analyzed by diverse cell- and molecular biological methods (e.g. flow cytometry or Western blotting). Upon interest, we can also bioinformatically evaluate in silico array data _
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Cell culture experiments with human and murine cell models, diverse cell- and molecular biological methods including e.g. flow cytometry, Western blotting; Histological staining and analysis of formaline-fixed and paraffin-embedded tissue. If the student is interested also performance and evaluation of array data or participation on xenograft experiments (anticancer activity against injected tumor cells) in SCID mice is possible.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
yes, preliminary readings
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
interest for scientific research and cancer, initative, willing to work hands on in a big team English or German course
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Miklos W et al Cancer Letters 2015; Karnthaler-Benbakka C. et al Angewandte Chemie 2014; Kryeziu K et al Mol Cancer Ther 2013; Jungwirth U et al Antioxid Redox Signal. 2011
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