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Effects of the cartilage destruction caused by vitamin D on the patients with osteoarthritis
Turkey (TurkMSIC) - Yildirim Beyazit University, Ankara
Ankara Yildirim Beyazit University Biochemistry Department
Prof.Dr. Leyla Didem Kozaci
Prof.Dr. Leyla Didem Kozaci E-mail: firstname.lastname@example.org Phone: +903123241555
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Osteoarthritis is a type of joint disease that results from breakdown of joint cartilage and underlying bone.It is the most commonly seen bone disorder in the society.It is the common reason of why elderly people have less joint movement ability.The most common symptoms are joint pain and stiffness.Initially, symptoms may occur only following exercise, but over time may become constant. Damage from mechanical stress with insufficient self repair by joints is believed to be the primary cause of osteoarthritis. Sources of this stress may include misalignments of bones caused by congenital or pathogenic causes; mechanical injury; excess body weight; loss of strength in the muscles supporting a joint; and impairment of peripheral nerves, leading to sudden or uncoordinated movements.Vitamin D with co-factors such as Magnesium, Calcium, and vitamin K help build cartilage as well as bone.It is known that MMP(matrix metallaoproteinase) and natural inhibitors are important in the destroying of cartilage.Some patients have respond to the vitamin D in the macrophages that are taken from the synovial fluid of patients with arthritis.It will be observed that vitamin D and receptors that are susceptible for the pathogenesis in this project.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should know the essentials about biochemistry, the biochemistry class at least one year and have knowledge about cartilage tissue .There is no legal limitations.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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