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Experimental research in sepsis and mechanisms of controlling the microcirculation physiology
Universidade Federal de Sao Paulo (UNIFESP)
Departamento de Cirurgia - Escola Paulista de Medicina / Universidade Federal de Sao Paulo (EPM/UNIFESP) R. Botucatu, 740 - 5 andar (lado direito de quem sai do elevador) - Vila Clementino, CEP:04023-062 - SP/SP
Jose Luis Martins
Ivan Hong Jun Koh
English, Spanish and Portuguese
Type of Research Project
- Basic science
What is the background of the project?
Sepsis is a leading cause of mortality in critically ill patients. The pathophysiology of sepsis involves a highly complex and integrated response, including the activation of various cell types, inflammatory mediators, and the hemostatic system. Recent evidence suggests an emerging role of the microcirculation in sepsis, necessitating a shift in our locus away Irom the macrohaemodynamics to ill icrohaemodynanmics in a septic patient. Sepsis is the most life threatening condition in Intensive Care Unity (ICU), with overall mortality around 50% of cases. From last two decades, none of new treatment ameliorated the death rate, demanding new approaches in terms of treatment, prevention and better understanding of its pathophysiology.
What is the aim of the project?
Understanding the varying mechanisms of controlling the microcirculation physiology and elaborate the therapeutics based guided on microcirculation dysfunction and its severity classification.
What techniques and methods are used?
Intravital microscopy, Sidestream Darkfield video-microscope, both for viewing and detecting the dysfunction degree; plus use of microsurgery techniques in order to install probes to monitor macrocirculation parameters to corroborate with the general hemodynamics.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Learn basic microsurgery technics; and learn microcirculation measuring devices. Participate in experiments, learn basic scientific methods.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There is no specific requirements.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Dellinger RP; Levy MM; Rhodes A; et al; Surviving Sepsis Campaign Guidelines Committee Including the Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41(2):580-637.
- Rhee C; Gohil S; Klompas M. Regulatory mandates for sepsis care?reasons for caution. N Engl J Med. 2014;370(18):1673-1676.
- Iwashyna TJ; Ely EW; Smith DM; Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304(16):1787-1794.
- Bone RC; Balk RA; Cerra FB; et al. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864-874.
- Levy MM; Fink MP; Marshall JC; et al; International Sepsis Definitions Conference. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003;29(4):530-538.
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