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Genetic and neuroendocrine contribution to autism spectrum etiology
Institute of Physiology
Prof. MUDr. Daniela Ostatnikova, PhD
MUDr. Katarina Babinska, Dr. Gabriela Repiska, Dr. Klaudia Kyselicova
Type of Research Project
- Basic science
What is the background of the project?
Genetic studies revealed the complexity behind the origin of autism. It was showed that approximately 1000 genes with high pleiotropy and low penetrance can play role in the etiology of autism. In parallel with the human part of research, animal models of autism will be analyzed. Cell cultures isolated from animal models represents the third level of our project that complements human and animal part. They enable the examination of the morphology and changes of candidate gene expression. We believe that this comprehensive project linking human, animal and cellular research can shed more light on the clarifying the complex relationships between genes and autistic traits. This project reflects current needs and challenges in autism research.
What is the aim of the project?
The main aim of the project is to search for etiopathogenic factors contributing to autism spectrum disorders. Within the homogenous subcategories, the relationship between genetic variants and phenotypical marker will be assessed. We have chosen candidate genes having a role in neuronal develop and connectivity, social and emotional interaction. Understanding of etiopathology is the basis for possible targeted interventions, which is crucial for the quality of life of patients and their families.
What techniques and methods are used?
Using standard European scales our diagnostics and measurements of metabolites in biological material using sensitive ELISA (enzyme-linked immuno sorbent assay) methods DNA/RNA isolation and analysis, taking of somatometric measuremets, it could be possible to create well defined homogenous categories based on predominant phenotype and search for the etiopathogenic factors contributing to autism etiology.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
will to work in a laboratory
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Experience in the laboratory. No laboratory skills are required, basic medical statistics is appreciated. Subjects passed: preclinical medical subjects (biology, biochemistry, anatomy, physiology).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents. Husarova VM; Lakatosova S; Pivovarciova A; Babinska K; Bakos J; Durdiakova J; Kubranska A; Ondrejka I; Ostatnikova D. Psychiatry Investig. 2016 Mar;13(2):174-83. doi: 10.4306/pi.2016.13.2.174.
- Bio-behavioral model of aggression in autism spectrum disorders-pilot study. Pivovarciova A; Hnilicova S; Ostatnikova D; Mace FC. Bratisl Lek Listy. 2015;116(12):702-6
- Testosterone and Androgen Receptor Sensitivity in Relation to Hyperactivity Symptoms in Boys with Autism Spectrum Disorders. Pivovarciova A; Durdiakova J; Babinska K; Kubranska A; Vokalova L; Minarik G; Celec P; Murin M; Ostatnikova D. PLoS One. 2016 Feb 24;11(2):e0149657. doi: 10.1371/journal.pone.0149657
- Synapse alterations in autism: Review of animal model findings. Zatkova M; Bakos J; Hodosy J; Ostatnikova D. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016 Jun;160(2):201-10. doi: 10.5507/bp.2015.066.
- Testosterone in relation to behavioral problems in pre-pubertal boys with autism spectrum disorders. Pivovarciova A; Durdiakova J; Hnilicova S; Filcikova D; Ostatnikova D. Physiol Res. 2015;64 Suppl 5:S595-601.
- Topoisomerases interlink genetic network underlying autism. Vokalova L; Durdiakova J; Ostatnikova D. Int J Dev Neurosci. 2015 Dec;47(Pt B):361-8. doi: 10.1016/j.ijdevneu.2015.07.009. Review.
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