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Autoimmune and viral models for immune-mediated diseases: multiple sclerosis, myocarditis and inflammatory bowel diseases
Japan (IFMSA-Japan) - Kindai University, Osaka(Kansai area)
Ikuo Tsunoda, MD, PhD, Professor
Ikuo Tsunoda, MD, PhD, Mitsugu Fujita, MD, PhD Ah-Mee Park, PhD, Fumitaka Sato, PhD, and Seiichi Omura, PhD
Type of Research Project
- Basic science
What is the background of the project?
Immune responses can protect hosts by killing microbes,while uncontrolled inflammation can damage tissue (immunopathology).Abnormal immune responses induced by autoimmunity and/or viral infections have been associated to cause immune-mediated diseases, including multiple sclerosis, myocarditis, epilepsy inflammatory bowel diseases, and ulcer. However, the precise pathomechanisms of the diseases are largely unknown.
What is the aim of the project?
The aim of the project is to clarify the pathophysiology of the immune-mediated diseases, and try to find the treatment of the diseases, using immunological, virological, and histological approaches.
What techniques and methods are used?
Mouse models for immune-mediated diseases will be analyzed using multivariate data (histology, clinical signs, real-time(RT)-polymerase chain reaction(PCR), microarray, RNA-sequencing, enzyme linked immunosorbent assay(ELISA), and plaque assays) with bioinformatics methods, such as principal component analysis, clustering.
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
Basic tissue culture and molecular biology techniques will be performed by the students under supervision, for example, cell culture, viral plaque assays, and PCR. The students will also learn how to analyze and evaluate their own experimental data.The student will attend weekly Department's metting on Research in Progress,where they are expected to present their experimental data as well as future experimental plans that are evaluated and discussed with faculty.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary reading materials, such as review and research articles and book chapters, will be provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic English communication skill
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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