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Ophthalmology Research Group of Miguel Servet University Hospital
Spain (IFMSA-SPAIN)-University of Zaragoza, Zaragoza
Luis E. Pablo
Pilar Calvo, Elena Garcia-Martin, Laura Gil, Victoria Pueyo, Miriam Idoipe, Mar
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
The main aim of the research project is the prevention, early detection and treatment of the chronic and degenerative ocular pathologies, using the last techniques of digital imaging analysis in Ophthalmology (such as the optical coherence tomography –OCT-, the Angio-OCT) and the evaluation of visual cognitive function in different pathologies and ages. To achieve this purpose our department has developed different research lines which focus on several important pathologies: The neuro-ophthalmology line analyses retinal and visual function changes in patients suffering from neurodegenerative processes (including Multiple Sclerosis, Parkinson disease, Alzheimer’s disease, Bipolar syndrome and Fibromyalgia) to develop new diagnostic tools, also for monitoring disease progression and treatment effectiveness. The glaucoma line evaluates the affectation of the different retinal layers using new software for OCT devices to provide early detection of glaucomatous damage, a better understanding of pathological changes in retinal cells caused by ocular hypertension and evaluate treatment effectiveness in these patients. The retina line uses the latest imaging techniques in Angiography and OCT analysis to evaluate early retinal changes caused by macular degeneration, diabetes mellitus and also retinal tumors. The children ophthalmology department has developed several evaluation tools for assessing neurodevelopment in premature children, and children with history of other intrauterus pathologies. For the past decade our department has developed these four lines of research using the last techniques of digital imaging analysis in Ophthalmology, and has produced more than 50 research articles which have been published in high impact factor journals (such as PlosOne, Ophthalmology and Multiple Sclerosis).
What is the aim of the project?
Structural and functional evaluation of the retinal nerve fiber layer as axonal damage biomarker in patients with neurodegenerative diseases, evaluation of the diagnostic capacity of a new method of colorimetric analysis in the head of the optical nerve in neurodegenerative diseases, neuro-development, evaluation of the visual function in patients with ocular hypertension or glaucoma, retinal pathologies and cataract surgery outcomes, new developments and technology testing
What techniques and methods are used?
structural and functional tests used in ophthalmology, study the diagnostic value of Laguna ONhE software for retinographic analysis, PreViAs questionnaire, optical coherence tomography, laser polarimetry and confocal laser scanning, measurement of best corrected visual acuity, aberrometry, pupillometry, perimetry, reading speed test, halometry and color vision and contrast sensitivity tests.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project is clinical
- the student will be allowed to work with patients
What are the tasks expected to be accomplished by the student?
- The student will mainly observe - they are not allowed to work with the patients. They will observe the practical experiments but will be highly involved in the analysis of the results. The student is expected to show interest and be responsible for their work. We want a student committed to their research exchange - and they are expected to be involved in our daily work.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There is theoretical teaching provided. The students will also be able to participate in our courses and seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must show interest on the project and be committed to the timetable. There are no legal limitations. They need to have studied ophthalmology. A white coat is also required.
Are there any legal limitations in the student’s involvement
Liability insurance needed
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- 1. Garcia-Martin E; Pueyo V; Almarcegui C; Martin J; Ara JR; Sancho E; Pablo LE; Dolz I; Fernandez J. Risk factors for progressive axonal degeneration of the retinal nerve fibre layer in multiple sclerosis patients. Br J Ophthalmol. 2011 Nov;95(11):1577-82. doi: 10.1136/bjo.2010.199232. Epub 2011 Jul 23. PubMed PMID: 21785155.
- 2. Pueyo V; Guerri N; Oros D; Valle S; Tuquet H; Gonzalez I; Ferrer C; Pablo LE. Effects of smoking during pregnancy on the optic nerve neurodevelopment. Early Hum Dev. 2011 May;87(5):331-4. doi: 10.1016/j.earlhumdev.2011.01.042. Epub 2011 Feb 24. PubMed PMID: 21353403.
- 3. Herrero R; Garcia-Martin E; Almarcegui C; Ara JR; Rodriguez-Mena D; Martin J; Otin S; Satue M; Pablo LE; Fernandez FJ. Progressive degeneration of the retinal nerve fiber layer in patients with multiple sclerosis. Invest Ophthalmol Vis Sci. 2012 Dec 17;53(13):8344-9. doi: 10.1167/iovs.12-10362. PubMed PMID: 23154461.
- 4. Rodriguez-Mena D; Almarcegui C; Dolz I; Pablo LE; Garcia-Martin E. Application of electrophysiological tests in the study of neurological diseases with visual involvement. Arch Soc Esp Oftalmol. 2012 Oct;87(10):311-4. doi: 10.1016/j.oftal.2012.09.001. English; Spanish. PubMed PMID: 23021227.
- 5. Calvo P; Ferreras A; Polo V; Guerri N; Seral P; Fuertes-Lazaro I; Pablo LE. Predictive value of retrobulbar blood flow velocities in glaucoma suspects. Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3875-84. doi: 10.1167/iovs.11-8817. PubMed PMID: 22589447; PubMed Central PMCID: PMC3390219.
- 6. Larrosa JM; Polo V; Ferreras A; Gil L; Fuertes I; Pablo LE. Predictive value of confocal scanning laser for the onset of visual field loss in glaucoma suspects. Ophthalmology. 2012 Aug;119(8):1558-62. doi: 10.1016/j.ophtha.2012.02.031. Epub 2012 May 12. PubMed PMID: 22584019.
- 7. Garcia-Martin E; Pablo LE; Herrero R; Satue M; Polo V; Larrosa JM; Martin J; Fernandez J. Diagnostic ability of a linear discriminant function for spectral-domain optical coherence tomography in patients with multiple sclerosis. Ophthalmology. 2012 Aug;119(8):1705-11. doi: 10.1016/j.ophtha.2012.01.046. Epub 2012 Apr 4. PubMed PMID: 22480742.
- 8. Bambo MP; Garcia-Martin E; Gutierrez-Ruiz F; Pinilla J; Perez-Olivan S; Larrosa JM; Polo V; Pablo L. Analysis of optic disk color changes in Alzheimer's disease: A potential new biomarker. Clin Neurol Neurosurg. 2015 May;132:68-73. doi: 10.1016/j.clineuro.2015.02.016. Epub 2015 Mar 9. PubMed PMID: 25797847.
- 9. Prieto E; Puente B; Uixera A; Garcia de Jalon JA; Perez S; Pablo L; Irache JM; Garcia MA; Bregante MA. Gantrez AN nanoparticles for ocular delivery of memantine: in vitro release evaluation in albino rabbits. Ophthalmic Res. 2012;48(3):109-17. doi: 10.1159/000337136. Epub 2012 Apr 21. PubMed PMID: 22538548.
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