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Improvement of noninvasive diagnosis and therapy of liver diseases
Germany (bvmd) - Ruprecht-Karls-Universitaet, Heidelberg
Medical Department (Gastroenterology, Hepatology), Salem Medical Center and Center for Alcohol Research, University of Heidelberg
Prof. Helmut K. Seitz
Prof. Sebastian Mueller and group members
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Our group has a long term interest both in basic science projects and translational projects directly linked to human diseases, namely liver diseases. A better understanding of liver disease and the development of novel diagnostic tools and therapeutic approaches is in the center of our basic research and translational research activities. One major expertise is the non-invasive detection and monitoring of chronic liver diseases. For example, our group deals with the recently introduced novel parameter of liver stiffness which has drastically improved the diagnosis of chronic liver disease. Liver stiffness has also given novel inspirations for a better molecular understanding of liver cirrhosis, the major end-stage disease of all liver diseases that still cannot be treated causally and whose pathophysiology is still poorly understood.
What is the aim of the project?
The aim of the project is to improve the diagnosis and the therapy of liver diseases. Furthermore we would like to achieve a better understanding of the underlying molecular mechanisms of liver diseases.
What techniques and methods are used?
For the liver iron measurement we use susceptometry, which is a measurement of paramagnetic, diamagnetic or ferromagnetic susceptibility For fatty liver measurement we use cap, ultrasound. For different liver stiffness measurements, we will use different fibrosis assessments.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The incoming student will be responsible for the clinical examination of the liver samples (on his own, with supervision) and the analyses of the clinical data, he/she will collect during his research exchange. He/she will also use different methods in the lab, such as susceptometry, depending on his/her project’s focus. All in all, he/she is highly welcomed to help our team actively by creating new data and input. He/she will take part in the group and lab meetings.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
yes if needed
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
interest in research work and corresponding motivation x Subjects passed: Physikum (exam between preclinical and clinical years), the student must be already in his clinical part of the studies
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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