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Analysis of the interaction between the gastrointestinal microbiota and the immune system
Austria (AMSA) - University of Graz, Graz
Institute of Pathology
Prof. Dr. H
Prof. Dr. Gorkiewicz
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Background: The composition of the gut microbiota will be determined using next generation metagenomic sequencing techniques such as high-throughput sequencing and shotgun metagenomic sequencing. The phenotype of the mucosal immune system will be determined. Samples from healthy individuals will be compared to samples from patients suffering from specific gastrointestinal diseases (e.g. IBD). Tissue samples will be histologically assessed using different staining techniques (e.g. typical stains, immunohistochemistry) Aim: Finding correlations between certain microbiome-types and certain immune system states Techniques and methods: Microbiome analysis through next generation sequencing, polymerase chain reaction, immunohistochemistry, histological tissue assessment.
What is the aim of the project?
Finding correlations between certain microbiome-types and certain immune system states
What techniques and methods are used?
Microbiome analysis through next generation sequencing, polymerase chain reaction, immunohistochemistry, histological tissue assessment.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Dedicated, accurate data gathering under the supervision of PhD students + the PI. The student will be able to decide if he/she is more interested in basic science or clinical science. The clinical aspect will include pathology related work such as histological assessment of tissue samples, description of microbiome compositions and autopsies. If the student if more interested in basic science, there would be the possibility to participate in lab work under the supervision of a PhD student. This would include lab techniques such as cell culture, flow cytometry, qPCR. If genuine interest and good skills are showed, the student will be allowed to carry out experiments in autonomy.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Regular journal clubs and thesis seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Montalban-Arques A. et al. Journal of Pathology 2016; Maynaud Ct et al. Nature 2012; Kump P et al. Inflammatory Bowel Diseases 2013
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