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The relationship between Angiotensin Ⅱ and low-density lipoprotein oxidation
China (IFMSA-China) - Wuhan University School of Medicine, Wuhan
Department of Biochemistry and Molecular Biology
Type of Research Project
- Basic science
What is the background of the project?
Atherosclerosis is a pathological process associated with the majority of cardio cerebrovascular diseases, and is a predominant cause of morbidity and mortality worldwide. LDL(low-density lipoprotein)is involved in the pathogenesis of atherosclerosis, and its oxidation is an essential step in initialing chronic inflammation.However, the precise mechanism underlying LDL oxidation has yet to be fully elucidated. Angiotensin (Ang), a peptide belonging to the renin-angiotensin system, induces vasoconstriction and subsequent increase in blood pressure.The inactive AngI is converted to AngII by angiotensin-converting enzyme (ACE). AngII is metabolized to AngIII, and subsequently converted to AngIV by two aminopeptidases. Among the Ang peptides, AngII is the most potent effector that plays an important role in maintaining homeostasis in the cardiovascular system by regulating blood volume, blood pressure, and peripheral vascular tone. Recent studies have implicated the involvement of AngII in the pathophysiology of atherosclerosis and cardiovascular diseases. However, the relationship between AngII and LDL oxidation remains unknown.
What is the aim of the project?
To find the relationship between AngiotensinⅡand LDL oxidation.
What techniques and methods are used?
Cell culture, Western Blot, Isolation of detergent-free lipid rafts, Mass spectrometry analysis
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student must learn to culture cells, because culturing cells is the first step of our experiment and their condition is important for the remaining experiment. Besides, he/she should understand the theories of techniques the project used, such as Western Blot, Isolation of detergent-free lipid rafts, Mass spectrometry analysis and so on. He/she also should learn to perform Western Blot,and it should be done on his/her own under supervision.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be a seminar every two weeks in our lab.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
- Jian Song; et al. "Native low density lipoprotein promotes lipid raft formation in macrophages:." Molecular Medicine Reports 13.3(2016):2087.
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