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Investigation of the therapeutic effects of natural products with vegetable origin on the side effects of antineoplastic drugs
Universidade Federal do Piaui (UFPI)
Department of Biochemistry and Pharmacology, Center of Health Sciences, Federal University of Piau
Prof. Dr. Fernando Aecio de Amorim Carvalho
Prof. Dr. Fernanda Regina de Castro Almeida
English, Spanish and Portuguese
Type of Research Project
- Basic science
What is the background of the project?
Cancer is a world public health problem, of great epidemiological relevance regarding its incidence, morbimortality and treatment difficulties. Most treatment possibilities carry side effects so severe that become a burden. The main complications faced when chemotherapy is chosen include neuropathies and haemorrhagic cystitis, for instance. This way, emerged the therapeutic need for adjuvants that reduce damage caused by those drugs. Natural products obtained from vegetables species arise as an option for future development of an efficient and safe medicine for treating cancer, as well as a possible adjuvant in antineoplastic therapy aiming to reduce side effects like neuropathic pain and cystitis.
What is the aim of the project?
To investigate antinociceptive and antiinflammatory activity of natural products, aiming future development of and adjuvant medicine for antineoplastic therapy, so as to reduce its side effects like neuropathic pain and cystitis.
What techniques and methods are used?
Induction of neuropathy with paclitaxel in mice Induction of cystitis with ifosfamida in mice Acute and chronic nociception measurement Quantification of Inflammatory parameters Execution of antioxidant analysis protocols Statistical analysis of the experimental collected data.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student should learn, through neuropathy and haemorrhagic cystitis induction with an antineoplastic agent, to evaluate nociception on this neuropathic pain model (mechanic nociception by Von Fey filaments and verification of thermal cold alodinia (acetone test) in times 0, 60, 120 and 180 min (acute) and for 7 days (subacute) and inflammation in the haemorrhagic cystitis model (macroscopic evaluation of vesical humid weight, bladder vascular permeability, and TNFα and IL1β identification with proper kits). In the study of the possible action mechanisms, the student should participate of antioxidants dosage (Superoxid Dismutase, reduced glutathione, lipidic peroxidation, nitrite and total proteins), and of inflammatory markers dosage (TNFα and IL1β). At the end of each protocol, the student should take part in the statistical analysis that will be conducted through the GraphPad Prism 6.0 software. Values will be expressed as average ± standard deviation. t Student tests and analysis of variance “one way” and “two way” (ANOVA) will also be conducted, followed by the Turkey or Bonferroni Test, with a significance level of p<0,05
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes. The laboratory organizes weekly scientific meetings to study review papers and full aticles related to the ongoing projects
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
To have studied and passed Pharmacology or an equivalent discipline in their instituition of origin.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- STEPHANIE GILBERTSON?WHITE; M.S.; R.N.;1 BRADLEY E. AOUIZERAT; PH.D.; M.A.S.;THIERRY JAHAN; M.D.;AND CHRISTINE MIASKOWSKI; R.N.; PH.D.; F.A.A.N. A review of the literature on multiple symptoms; their predictors; and associated outcomes in patients with advanced cancer. Palliative and Supportive Care (2011); 9; 81?102.
- Hama A; Takamatsu H. Chemotherapy-Induced Peripheral Neuropathic Pain and Rodent Models. CNS Neurol Disord Drug Targets. 2016;15(1):7-19.
- Payne H; Adamson A; Bahl A; Borwell J; Dodds D; Heath C; Huddart R; McMenemin R; Patel P; Peters JL; Thompson A. Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges. BJU Int. 2013 Nov;112(7):885-97.
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