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The role of the mRNA degradation machinery in neurodegeneration
Greece (HelMSIC) - University of Crete, Heraklion
Neurogenetics and ageing laboratory Department of Basic Sciences, Faculty of Medicine, University of Crete Heraklion 71110, Crete, GREECE and Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas
English and Greek
Type of Research Project
- Basic science
What is the background of the project?
The molecular mechanisms underlying neurodegeneration are poorly understood. Previous studies have shown that interventions altering mRNA translation rates influence ageing and susceptibility to neurodegeneration. Accumulating findings indicate that the translational status of an mRNA reflects a constant competition between the assembly of the translational machinery and the assembly of the decay machinery. This project addresses the question of whether key factors of the mRNA degradation machinery are functionally linked with ageing and age-related neurodegeneration.The central aim of this project is to delineate the role of the mRNA decay pathway in promoting neurodegeneration using the nematode Caenorhabtitis elegans as a model organism.To achieve our goal we establish C. elegans models of human neurodegenerative diseases (for example, Parkinson
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student will be introduced into C. elegans research (preliminary readings) focusing on the work performed in the Neurogenetics and ageing laboratory headed by Prof. Tavernarakis. In addition, he/she is excpected to attend our weekly group meetings as well as the regularly organised IMBB colloquia.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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