Projects
Name
Health Effects and Attributable Risk Assessment Study (HEARAS) of AmbientPM2.5 in Beijing
University
China (IFMSA-China) - Peking Union Medical College, Beijing
Domain
Epidemiology
Departement
School of Basic Medicine, Peking Union Medical College No. 5 Dong Dan San Tiao, Dongcheng District,Beijing 100005, China
Head
Susu Liao
Tutor
QunXu
Languages
English Chinese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
PM2.5 is an emerging public health challenge in Beijing, China. Previous studies suggested that PM2.5can increase risk of chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM). However, the pre-clinicalbiomarker change and population attributable fraction of ambient PM2.5 have not been well definedamong Chinese population in Beijing. 1.To accomplish the retrospective baseline data collection that recorded before 2015 for the selected six communities. 2.To evaluate and modify the chronic disease questionnaires. 3.To implement validation study and develop primary land use regression (LUR) based on the long time series data of 35 fixed monitoring sites, then apply the established LUR model to the estimate the individual outdoor PM2.5 exposures for the participants in six communities. 4.Accomplish the recruitment of health population panel that is PM2.5-circulating biomarker panel (PCBP). 5.To develop study manuals including: exposure measurement manual, biomarkers detect manual, statistical analysis manual, Panel and cohort follow up manual. The first stage of field investigation and implementation has been accomplished during October to December in 2016. Inclusively, the pilot study or main study sites were selected and set up. In this stage, we screened 6 representative filed sites as the pilot sites according to the differences characteristic of PM2.5 spatial distribution and lifestyle pattern of urban and rural areas in Beijing. These sites were spatially scattered and covered different air pollution levels ranging from the highest at south to the middle at core urban area and lowest at north, the population including office workers, factory workers and famers. Specifically, China Coal Energy Group community at Dongcheng District, China Coal Research Institute community at Chaoyang District, Beijing Coal Mining Machinery community at Fangshan district, Kangju community at Daxing District, Qiannantai and Liuhegou village at Miyun District were selected as the pilot areas. Population health survey including questionnaire for participants, blood sampling, urine sampling, blood pressure, and other indices were conducted synchronized with indoor air and outdoor PM2.5sampling. Field work in these six communities were conducted and finished during Oct to Dec, 2016, the bio-samples and indoor and outdoor PM2.5 samples were obtained before heating period and after heating period, lab analysis for PM2.5 organic and inorganic components were undergoing. We have also collected hourly PM2.5 and the others pollutants (PM10, CO, NO2, SO2, O3) of 35 monitoring sites, meteorological data (wind speed, barometric pressure, temperature, relative humidity, etc) in Beijing during the same time.
What is the aim of the project?
1.To accomplish the retrospective baseline data collection that recorded before 2015 for the selected six communities. 2.To evaluate and modify the chronic disease questionnaires. 3.To implement validation study and develop primary land use regression (LUR) based on the long time series data of 35 fixed monitoring sites, then apply the established LUR model to the estimate the individual outdoor PM2.5 exposures for the participants in six communities. 4.Accomplish the recruitment of health population panel that is PM2.5-circulating biomarker panel (PCBP). 5.To develop study manuals including: exposure measurement manual, biomarkers detect manual, statistical analysis manual, Panel and cohort follow up manual.
What techniques and methods are used?
questionnaire for participants, blood sampling, urine sampling, blood pressure, data analysis
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
1 Participating in the design and improvement of the questionnaire . 2 Participating in data entry and some simple data processsing. 3 Participating in coordination of field work such as name encoding and maintenance of order 4 Pretreatment of some biological samples 5 Laboratory measurement of some indicators that has to be done under supervision.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, there will be lectures, courses, seminars and some basic operation in experiment.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
data processing software
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
- Pre-Medical students from the American-British system
Articles
- Wu C F; Shen F H; Li Y R; et al. Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects.[J]. Science of the Total Environment; 2016; s 569?570:300-305.
- Xian Z; Staimer N; Tjoa T; et al. Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential[J]. Environmental Health; 2016; 15(1):81.
- aenen N D; Provost E B; Viaene M K; et al. Recent versus chronic exposure to particulate matter air pollution in association with neurobehavioral performance in a panel study of primary schoolchildren.[J]. Environment International; 2016; 95:112-119.