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Sprouty Proteins as modulators of signaling in lung cancer
Austria (AMSA) - University of Vienna, Vienna
Institute of Cancer Research, Borschkegasse 8a, A-1090 Vienna
Assoc Prof. Dr Hedwig Sutterlüty-Fall, Sandra Neubauer
Type of Research Project
- Basic science
What is the background of the project?
Background: Sprouty proteins are important modulators of cell signaling. Dependent on the cellular background or the growth factor responsible for the activation of the signal cascades they interfere with the signal intensity or their presence activates the signaling process. Therefore, they can function as tumor suppressors or oncogenes. In lung cancer, Sprouty2 is shown to function as tumor suppressor.
What is the aim of the project?
In an earlier performed sequencing project of lung cancer cell lines we found 4 different mutations within the coding sequence of Sprouty2. Therefore, we aim to investigate how these mutations influence localization of Sprouty2 protein and its interference with signaling.
What techniques and methods are used?
Techniques and methods: Cell cultivation methods, ectopic expression of proteins using recombination and replication deficient adenoviruses, immunoblotting cell fractionation, adenovirus production and purification
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will assist the tutor and the Technical Assistant of the lab in performing the described project and at the end of the month, s/he will be able to perform some of the methods (Cell cultivation, immunoblotting cell fractionation,…) her/himself. S/he will also learn more about the principles of signal transduction and the importance of Sprouty2 in lung cancer.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There is a lab seminar, the student will actively participate
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Students in biomedical fields
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