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Morphological markers of human and experimental animals liver cells within its organization during development
Serbia (IFMSA-Serbia) - University of Nis, Nis
Department of Histology and Embryology, Faculty of Medicine University of Nis, Serbia
Prof. Dr. Goran Radenkovi
Assist. Dr. Marko Jovi
Type of Research Project
- Basic science
What is the background of the project?
The intensive development of molecular marking cell antigens in tissues, has led to an increase in the precision of research tissue organization. Understanding this concept is strictly dependent on the application of micro-morphological methods of research, with the aim of highlighting the spatial and dynamic relationships between cellular components. This research will approach the analysis of biopsy samples of embryonic, fetal and adults, as well as experimental animals. In the analysis of literature related to the development of human liver, which includes the development of lobular organization, vasculogenesis and angiogenesis, histological and immunohistochemical characteristics of cell populations in the liver, we can see a relatively small number of data, especially regarding the presentation of quantitative findings for all these cells, in the light of the dynamics of the liver development. It is therefore necessary to determine the presence, topographic localization, immunohistochemical and morphometric characteristics of cell populations in the liver during its embryonic and fetal development, as well as their attitude and relationship with phenotypic variants of endothelial cells of blood and lymphatic vessels.
What is the aim of the project?
This course, as a one part of project, is offered to provide students with knowledge that helps bridge the gap between a number of the basic sciences, as well as serving to introduce structures and concepts that are studied later in depth in physiology, pathophysiology, pharmacology and pathology. Wherever it is possible, the clinical significance and application to subsequent courses is pointed out via laboratory sessions and the clinical correlates that follow the post-lab sessions. Employing these functional seeing it has been shown to help students in clinical applications, improve student-student interactions, improve grades and help learning in next years.
What techniques and methods are used?
The methods that will be used to visualize the arrangement and composition of cells and tissues are basic and state some of the general principles of tissue fixation, staining, localization and examination. Matherial that is going to be used can be from human or animal origin taken by autopsies, biopsies, aspirates and smears. The meaning of commonly used terms in histologic methods, so as staining properties, classical histochemistry, cytochemistry, immunochemistry will be offered too.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
When student have finished this research course, as a part of project, he/she will be able to describe how cells and extracellular components of the human body are composed and arranged to form tissues, organs and system of organs and their origin and the way how do they form during prenatal life. Student will be able to recognize the microscopic structure of nearly all of the cells and tissues using the light microscope and in electron micrographs. An ability to relate this knowledge and understanding to gene function and protein synthesis, as well as to cellular functions, interactions and the roles of extracellular structures, should be achieved.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
preliminary readings, courses, seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system - Students in biomedical fields - Dental medicine students (IADS members)
- Si-Tayeb K; Lemaigre FP; Duncan SA. Organogenesis and development of liver. Developmental Cell 2010; 18: 175-189.
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