Projects
Name
Molecular analysis for subgroups of prostate and kidney cancer
University
Germany (bvmd) - Ruprecht-Karls-Universitaet, Heidelberg
Domain
Oncology
Departement
Section of translational Uro-Oncology, medical oncology
Head
Dr. Jaeger
Tutor
Dr. Gruelich
Languages
English, German
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No Yes Yes No No Yes Yes No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In collaboration with the National Center for Tumor Diseases Heidelberg, we want to gain more knowledge about prostate and kidney cancer. Prostate cancer is the most frequently diagnosed cancer in Germany in males. Prostate and Kidney cancer are genetically very diverse tumors. Their genomic differences make them easier to recognize, to differentiate and to find. We perform DNA sequencing analyses in patients with high risk disease in order to study the correlations between the genetic and the risk of the tumor and the course of the disease. What is the aim of the project? The aim of the project is it to correlate genetic subgroups with disease courses and the genetic risk of the development of these cancer types. What techniques and methods are used? Clinical examinations on patients followed by the analyses of the clinical data, which will be collected by the student. After that he/she will be helping the team with next generation sequencing and Immunohistochemistry to study the correlations between the genetic and the risk of the tumor and the course of the disease. He/she will be responsible for doing real time polymerase chain reactions on his/her own. The student will microscope different tissues of prostate and kidney cancer types in order to learn more about the disease course
What is the aim of the project?
The aim of the project is it to correlate genetic subgroups with disease courses and the genetic risk of the development of these cancer types.
What techniques and methods are used?
Clinical examinations on patients followed by the analyses of the clinical data, which will be collected by the student. After that he/she will be helping the team with next generation sequencing and Immunohistochemistry to study the correlations between the genetic and the risk of the tumor and the course of the disease. He/she will be responsible for doing real time polymerase chain reactions on his/her own. The student will microscope different tissues of prostate and kidney cancer types in order to learn more about the disease course
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
_The student will be responsible for clinical examination (on his own, with supervision) and the analyses of the clinical data, he/she collected. _He/she will perform microscopy of the different tissues of prostate and kidney cancer types. _During the lab work, he/she will be helping the team by sequencing and doing immunohistochemistry after an introduction of these techniques. -He/she will be responsible for doing real time polymerase chain reactions on his/her own. - Take part in the lab meetings, tumor boards and lectures and prepare a presentation of the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures, Tumor boards, Lab meeting
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Medium clinical skills, basic statistics skills. Subjects passed:internal medicine Previous experience with: Oncology. No legal Limitation. A conference call beforehand is necessary.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
- PARP inhibition in BRCA-2 mutated prostate cancer; annals of Oncology; September 2016