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Characterization of the host immune response to Candida species cells
Portugal (PorMSIC) . Univesity of Porto - Biomedical Sciences Institute Abel Salazar, Porto
Immunology and Pharmacology. ICBAS ? U.Porto.
Prof. Paulo Correia de S
Spanish; French; Portuguese; Italian
Type of Research Project
- Basic science
What is the background of the project?
Candida species are causative of human infections that may range from cutaneous infections to systemic, potentially life threatening, infections. Studying how different Candida species interact with host immune cells and ensuing functional consequences will be helpful knowledge towards the development of immune- mediated prevetive or therapeutic stategies to manage these infections.
What is the aim of the project?
The aim of the project is the characterization of immune mediators (eg. cytokines) produced by leukocyte cell populations challenged in vitro or in vivo with different Candida species and the importance of particular fungal antigens in the type of elicited immune response.
What techniques and methods are used?
Basic microbiological techniques; In vitro leukocyte cell cultures; Flow cytometry; Enzyme-linked immunosorbent assay, Polymerase-chain reaction; Immunohistochemistry. The techniques are intended to grow the different fungi and to characterize the immune response of fungal-challenged immune cells.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The performance of the techniques by the student alone or under supervision will depend on the student’s demonstrated knowledge and experience. The student will grow Candida cells, differentiate or culture immune cells in vitro (eg macrophages, dendritic cells; lymphocytes) and analyze their response to a fungal challenge using different techniques, such as Flow cytometry, Enzyme-linked immunosorbent assay, Polymerase-chain reaction and Immunohistochemistry.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
preliminary readings, lectures, seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in cell biology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Carneiro et al. (2016) Acta Biomater. 39:133-45.
- Carneiro et al. (2015) Eur J Pharm Biopharm. 89:190-200.
- Correia et al. (2010) Infect Immun. 78:4839-49.
- Vilanova et al. (2004) Immunology. 111:334-42.
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