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Effect of TP53 gene mutations on glucose metabolism and angiogenesis in ovarian cancer
Universite Saint-Joseph (USJ)
Cancer and Metabolism Laboratory
Dr. George Hilal
Dr. Roula Tahtouh
English or French
Type of Research Project
- Basic science
What is the background of the project?
P53 is very known tumor suppressor protein and considered as the guardian of our genome. In addition, and recently, P53 has been found to play a role in apoptosis, hypoxia and cellular metabolism including the glucose metabolism. In addition, caloric restriction, especially glucose restriction has been proved to reduce tumor size, enhances the response to chemotherapy and decreases its side effects. However the exact molecular role of P53 in metabolism is not clearly elucidated. Since the gene of P53 is often mutated in all type of cancers including the ovarian cancer, our laboratory is aiming to investigate the role of different mutations in P53 gene on glucose metabolism and angiogenesis. The aim of the project is to correlate the different P53 mutations on glucose metabolism and angiogenesis. The techniques used include Cell culture, RNA extraction, DNA extraction, RT-PCR (reverse transcriptase- Polymerase Chaine Reaction) technique and quantitative PCR
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific requirements. The student should be motivated and read the preliminary readings below and those sent by the tutor prior to the start of exchange
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Nat Rev Mol Cell Biol. 2015 Jul;16(7):393-405. doi: 10.1038/nrm4007. p53 in survival; death and metabolic health: a lifeguard with a licence to kill. Kruiswijk F1; Labuschagne CF1; Vousden KH2.
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