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Placental Development and Pregnancy Related Diseases
American University of Beirut
Department of Anatomy, Cell Biology and Physiological Sciences
Dr. Elie El Chaer
Dr. Georges Daoud
Type of Research Project
- Basic science
What is the background of the project?
During human development, the first cell differentiation process is the formation of the trophectoderm layer that will give rise to all cell types of the placenta. These cells are classified into two categories: villous and extravillous cytotrophoblast. The extravillous cytotrophoblasts give rise to invasive, endovascular and proliferative cytotrophoblast which play a major role in the implantation process. The villous cytotrophoblast will give rise to a layer of syncytiotrophoblast formed by fusion of the underlying cytotrophoblast. This syncytium structure plays a major role in the exchange between mother and fetus including nutrients, gases and wastes. Therefore, these differentiation processes are very important for normal placental development and are reported to be defective in many pregnancy related diseases such as pre-eclampsia, IUGR and gestational diabetes.
What is the aim of the project?
studying trophoblast differentiation
What techniques and methods are used?
cell culture, real time PCR
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
once they join the Lab, they will have some readings.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific requirement. The student should be motivated to learn, and read all preliminary readings below and sent by the tutor before the exchange.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Orendi K; et al. (2010). The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins DOI: 10.1530/REP-10-0221
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