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Anticancer activity of natural and synthetic molecules - molecular and cell basis
Universidade de Ribeirao Preto (UNAERP)
Biotechnology unit, university of Ribeirao Preto, Sao Paulo, Brazil
Prof.Dra. Suzelei de Castro Franca
Portuguese, Spanish, German (basic).
Type of Research Project
- Basic science
What is the background of the project?
Cancer is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Globally, nearly 1 in 6 deaths is due to cancer. Approximately 70% of deaths from cancer occur in low- and middle-income countries. The estimate for Brazil, biennium 2016-2017, indicates the occurrence of about 600 thousand new cases of cancer. Currently, much anticancer therapy uses drugs that affect oncogenes/tumor suppressor genes, such as p53 (up-regulation) and Sp1(down-regulation).The project aims the identificantion of molecules with anticancer activity and study of the molecular basis of this activity.
What is the aim of the project?
The aim of the project is to identify molecules with cytotoxic activity against cancer cell lines (osteosarcoma, stomach, breast); It will be made identification of molecular target.
What techniques and methods are used?
This study includes cell biology assays such as Cell Proliferation Assay with Dimethylthiazole bromide (MTT) kit, migration, invasion, molecular biology assays such ass Polymerase Chain Reaction, clonidine. Bioinformatics is used as well.
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student must have previous experience in laboratories and research. He also should have a basic knowledge of molecular biology, cancer and anticancer activity (Basic), only in order to figure out the research and learn about the project.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Students are encouraged to read articles from any research group and attend seminars.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Cell biology and molecular biology, knowledge about molecular cancer pathways.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Anti-cancer activity of trans-chalgone in osteosarcoma. Molecular carcinogenesis 2016; ss(10):1433-48 Silva and cols
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