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Testing compounds that can selectively kill aneuploid cells
the Netherlands (IFMSA-NL) - University of Groningen, Groningen
European Research Institute for the Biology of Ageing
Gerald de Haan
Type of Research Project
- Basic science
What is the background of the project?
NOTE: for this project, your AF has to be sent at least 4 weeks in advance!!!! Aneuploidy, an abnormal number of chromosomes in a cell, is a hallmark of cancer. As the aneuploid DNA content discriminates the cancer cells from the healthy cells, aneuploidy is a promising therapeutic target. However, in order to come to drugs that selectively kill aneuploid cells (and not cells with a normal DNA content), we first need to better understand how cells (and tissues) respond to aneuploidy. This is the bread and butter of our lab. We have developed mouse models in which we can study the consequences of aneuploidy. Our models are providing leads to possible mechanisms that aneuploid cells require to survive. In this project, you will be involved in validating such aneuploidy-induced responses and/or involved in testing drugs that have the potential to selectively kill aneuploid cells. The exact content of the project will be determined upon your application for a short stay in the lab (as projects constantly change). The project will involve tissue culturing, karyotyping (determining the chromosome number cells), possibly time lapse imaging and some biochemistry (e.g. western blotting)
What is the aim of the project?
In this project, you will be involved in validating such aneuploidy-induced responses and/or involved in testing drugs that have the potential to selectively kill aneuploid cells.
What techniques and methods are used?
The exact content of the project will be determined upon your application for a short stay in the lab (as projects constantly change). The project will involve tissue culturing, karyotyping (determining the chromosome number cells), possibly time lapse imaging and some biochemistry (e.g. western blotting)
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will be trained by a postdoc, PhD student or technician to perform the experiments for the project. The student will learn to tissue culture independently (ideally the student already has some experience). Furthermore, the student will together with a postdoc/PhD student setup time lapse experiments. The student will be taught to analyze the data him/her self. Depending on the previous experience of the student, he/she will work more independently in the lab.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will attend a number of meetings: 1:1 meetings with direct supervisor and PI, weekly department meetings, weekly lab meetings, bi-weekly literature discussions and 1-2 seminar series.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student is required to have some lab experience and ideally some tissue culture experience. Also, the student must have passed the following subjects in their studies: Basic biology. Molecular biology is helpful, but most important is an genuine interest in basic science.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Bakker et al; Genome Biology; 2016 17(1):116 Foijer et al; PNAS 2014; Foijer et al; PNAS 2013
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