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Treatment of traumatic memories with adrenoceptor antagonists and possible implications in anxiety disorders
Portugal (PorMSIC) . Univesity of Porto - Biomedical Sciences Institute Abel Salazar, Porto
Departamento de Imuno-fisiologia e farmacologia. Instituto de Ciencias Biomedicas Abel Salazar. Rua Jorge Viterbo Ferreira, 228, Edificio 2, piso 4. 4050-313 Porto.
Paulo Correia de Sa
Monica Moreira Rodrigues
Spanish and Portuguese
Type of Research Project
- Basic science
What is the background of the project?
In anxiety disorders contextual factors contribute to fear generalization, traumatic memory retrieval and relapse after exposure therapy. The mechanisms that underlie the recovery of emotional associations due to context may have implications for the study and treatment of anxiety disorders. The understanding of those mechanisms is essential to discover new treatments of traumatic memories.
What is the aim of the project?
The aim of this project is to evaluate behavior and related mechanisms in mice treated with adrenoceptor agonists and antagonists.
What techniques and methods are used?
Handling and simple manipulation with experimental mice. Behavioral tests (fear conditioning, open field, plus maze, swim forced test). Evaluation of specific mRNA by Reverse transcription polymerase chain reaction (RT-PCR). Quantification of catecholamines by High performance liquid chromatography (HPLC) with?electrochemical detection?(ED). Imunohistochemistry.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Initially all procedures will be under supervision. Afterwards, the student will do on his own simple manipulations with mice, behavioral tests, solutions preparation and quantification of catecholamines by HPLC-ED.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Initially the student will read papers/manuscripts/protocols.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge in physiology and pharmacology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Alves E; Lukoyanov N; Serrao P; Moura D; Moreira-Rodrigues M (2016) Epinephrine increases contextual learning through activation of peripheral beta2-adrenoceptors. Psychopharmacology (Berl) 233: 2099-108.
- Sherin JE; Nemeroff CB (2011) Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues in clinical neuroscience 13: 263-278.
- Toth M; Ziegler M; Sun P; Gresack J; Risbrough V (2013) Impaired conditioned fear response and startle reactivity in epinephrine-deficient mice. Behav Pharmacol 24: 1-9.
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