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Enhancing Prostate Cancer Sensitivity to TRAIL Anti-tumor Effects by Targeting CXCR4
Sultan Qaboos University
Department of Pharmacology and Clinical Pharmacy College of Medicine and Health Sciences
Dr.Yousuf Al Suleimani
Ibrahim Hamdy Younos
Type of Research Project
- Basic science
What is the background of the project?
Many antitumor medications have been developed for prostate cancer but their intolerable systemic toxicity often limits their clinical use. Cytotoxic drugs kill tumor cells by a variety of mechanisms translated into signals for apoptosis. Although the relative 5-year survival rate is nearly 100%, drug resistance remains a significant obstacle in the control of prostate cancer; with inhibition of apoptosis as one of the mechanisms behind this phenomenon. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered a promising cancer therapeutic target which can specifically kill transformed cells and spare normal cells. The CXCL12/CXCR4 axis has been shown to play important roles in prostate tumor cell proliferation, angiogenesis, and metastasis. Amongst the patients
What is the aim of the project?
Examining the effect of the CXCR4 antagonist, AMD3100, on the therapeutic effects of TRAIL-regulated prostate cancer apoptosis, growth and metastatic potential in vitro within cell lines having different metastatic potential & in vivo within prostate cancer murine models.
What techniques and methods are used?
• Cancer cell culture • RT-PCR (Reverse transcription polymerase chain reaction) • Western blotting • Viability assay • Migration and Invasion Assay
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will be involved in performing the following: handling Cell cultures and that is by: maintaining, subculture, freezing, thawing, treating with drugs and harvesting the cell cultures. Students will also be involved in Whole cell lysate preperation , protein quantification and Western blot. Students will be recording the findings, analyzing the data and comparing them with previously recorded data. Student will be under supervision during conduction of the experiment
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific outcome is expected
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- ? LNCaP Model of Human Prostatic Carcinoma. ICANCER RESEARCH 43. 1809-1818. April 1983 ? Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells. Int. J. Mol. Sci. 2010; 11; 1-13 ? Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci. March 2008; vol. 99; no. 3.
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