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Chemoresistance in breast cancer: The role of E2F Transcription Factor 1 (E2F1) activation and its modulation by Protein Kinase B (Akt/PKB) pathway.
Sultan Qaboos University
Department of Allied Health Sciences College of Medicine & Health Sciences
Dr. Shadia Al Bahlani
Dr. Shadia Al Bahlani, Ms. Nadia Al Abri and Ms. Buthaina Al Dhahli.
Type of Research Project
- Basic science
What is the background of the project?
Breast cancer is the most common cancer among women worldwide, accounting for more than half a million death annually (WHO). Platinum-based chemotherapy is an effective anti-cancer drug used in the treatment of some types of breast cancer such as the Triple-Negative Breast Cancer (TNBC). Although most patients are at first responsive, eventually relapse and become resistant to additional treatment. Drug resistance is a multi-factorial event and involves changes in the expression of various protein factors contributing to drug-induced apoptosis. Upon the several identified factors, E2F1 has been shown to play an important role in controlling both cell-cycle progression and apoptosis in response to DNA damage. Once activated, E2F1 can then trigger apoptosis through both p53-dependent and independent mechanisms. Akt is another important player that promotes cell survival and suppresses apoptosis either by activating and/or inhibiting apoptotic proteins. Aim : The proposed study will focus on revealing the underling mechanisms of E2F1 and Akt interaction and how such interaction may enhance breast cancer cell sensitivity to drug-induced apoptosis. Techniques and methods used: ? Cell Clulture ? Western Bloting ? Apoptosis Assay
What is the aim of the project?
The proposed study will focus on revealing the underling mechanisms of E2F1 and Akt interaction and how such interaction may enhance breast cancer cell sensitivity to drug-induced apoptosis.
What techniques and methods are used?
• Cell Clulture • Western Bloting • Apoptosis Assay
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be involved in answering one of the research questions by performing: Cell Clulture, Western Bloting and Apoptosis Assay, to find the underling mechanisms of E2F1 and Akt interaction. The Students will be recording the findings, analyzing the data and comparing them with previously recorded data. Student will be under supervision during conduction of the experiment.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have some background in basic sciences
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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