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Bisphenol A effect on hepatic Growth hormone actions
Sultan Qaboos University
Department of Clinical Biochemistry
Dr. Khalid Al-Rasadi
Dr Fahad AL Zadjali
Type of Research Project
- Basic science
What is the background of the project?
Description of the project : Bisphenol A is a known endocrine disruptive compound that is released from polycarbonated plastics. Environmental prrotection agencies regulate the dose of bisphenol A in plastic by-product due to it adverse effect on reproduction. It mediates its actions through binding to estrogen receptor. Estrogen is nown to interact and inhibit growth hormone actions in the liver. It is not known if bisphenol A inhibits growth hormone actions Aim : - Study growth hormone signaling in liver cells. - Study if bosphenol A inhibits growth hormone actions using liver cells. Techniques and methods used: - Production of cDNA clones of growth hormone receptor - over-express the receptors in cell line - stimulate liver cells with growth hormone - perform western blot to study protein activation
What is the aim of the project?
- Study growth hormone signaling in liver cells. - Study if bosphenol A inhibits growth hormone actions using liver cells.
What techniques and methods are used?
Production of cDNA clones of growth hormone receptor - over-express the receptors in cell line - stimulate liver cells with growth hormone - perform western blot to study protein activation
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
First the students will be given a general exposure to the project and they will be trained as well. The students will be involved in performing the following: stimulating liver cells with growth hormone and performing western blot to study protein activation. Students will be recording the findings, analyzing the data and comparing them with previously recorded data. Student will be under supervision during conduction of the experiment.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have some background in basic sciences
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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