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The role of phosphatidylinositide 3-kinase (PI3K)/ protein kinase B(AKT)/mammalian target of rapamycin (mTOR) pathway in oral squamous cell carcinoma
Portugal (PorMSIC) - University of Coimbra, Coimbra
Faculty of Medicine University of Coimbra, Portugal
Prof Duarte Nuno Vieira
Marilia Dourado and Catia Domingues
English and Portuguese
Type of Research Project
- Basic science
What is the background of the project?
Oral cancer, most commonly oral squamous cell carcinoma (OSCC), represents about 90% of oral cancer patients with a worldwide incidence around 300 000 cases / year. A substantial number of these patients may become resistant to chemotherapy or relapse, having a particularly poor survival rate. The phosphatidylinositide 3-kinase (PI3K)/ protein kinase B(AKT)/mammalian target of rapamycin (mTOR) - PI3K/AKT/mTOR pathway regulates cell proliferation, differentiation, cellular metabolism, and cytoskeletal reorganization leading to apoptosis and cancer cell survival.
What is the aim of the project?
To evaluate the participation of PI3K/AKT/mTOR in OSCC development.
What techniques and methods are used?
Cell culture, Cell proliferation/viability was assessed by the rezasurin metabolic assay, Western Blot, Flow cytometry
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
After a short period of adaptation in which the techniques and procedures will be explained to him/her to have in a lab work, the Student will participate in lab work performing simple task such as cell culture, assesment of cell proliferation/viability by the rezasurin metabolic assay,western Blot and flow cytometry. First the student will peform under supervision, depending of his progress he will be able to perform them alone.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Subjects passed: Biochemistry and molecular oncobiology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Katrinakis NG; Tourvas AD; Laskaris G; Gorgoulis VG.?Advances in the biology of oral cancer.?Oral Oncology (2007) 43; 523? 534
- Adjei IM and Blanka S. Modulation of the Tumor Microenvironment for Cancer Treatment: A Biomaterials Approach. J. Funct. Biomater. 2015; 6; 81-103; doi:10.3390/jfb6010081
- Gao W; Li JZH; Chan JYW; Ho WK; Wong TS.?mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer. ISRN Otolaryngology; Volume 2012; Article ID 953089; 7 pages doi:10.5402/2012/953089
- Leemans CR; Braakhuis BJM; Brakenhoff RH.?The molecular biology of head and neck cancer.?Nature Reviews Cancer | AoP;16 December 2010; doi:10.1038/nrc2982
- Meric-Bernstam F; Gonzalez-Angulo AM.?Targeting the mTOR Signaling Network for Cancer Therapy.?Journal of Clinical Oncology. Volume 27; Number 13; 2009
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