Projects
Name
[Guadalajara] Effect of Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome
University
Universidad de Guadalajara
Domain
Endocrinology
Departement
Vascular mechanics department, Institute of clinical and experimental therapeutics (INTEC), Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara. Guadalajara Jalisco, Mexico
Head
Prof. Dr. SNI1 Fernando Grover Paez
Tutor
Patricia Quezada Fernandez
Languages
English and Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes Yes Yes Yes Yes Yes No Yes Yes Yes No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In Mexico, obesity is a major public health problem. It has triggered a proportional increase in the development of Metabolic Syndrome (METS). Abdominal obesity is one of the main components of METS which is generally associated with insulin resistance / hyperinsulinemia. There is evidence that the visceral fat has an important bearing on many factors of METS, like: glucose intolerance, hypertension, dyslipidemia, and insulin resistance. Among non-pharmacological therapies, there is recently the use of Conjugated Linoleic Acid (ACL) and leucine where in its assigned properties include weight reduction, anti-atherogenic , hypocholesterolemic and immunostimulant effect and anticarcinogenic properties. Regarding weight reduction dominates the mechanism of action anti-lipolytic effect. But, studies are needed to link this consumption with the increase or decrease on visceral fat in individuals with METS__
What is the aim of the project?
The main objective is to compare the effect of the administration of ACL/Leucine vs. Metformin on visceral fat area in patients with METS.
What techniques and methods are used?
We will conduct a double-blind trial, randomized, on 4 groups, each group with 26 male and female patients of 35-65 years of age with METS diagnosed by International Diabetes Federation criteria. Visceral fat area, epicardial fat, body weight, body fat, body mass index (BMI) and blood pressure will be determined during the inicial and final visit, likewise, hemodynamics parameters of arterial stiffness like aortic pulse wave velocity (PWVao), central pulse pressure (PPao), aortic augmentation index (IAxao) and central systolic blood pressure (cSBP) by an oscillometric monitoring system via BPLab
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
1
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous research incursion is desirable but not limiting. Basic knowledge of Pharmacology and research. Disclosure limitations of a double-blind trial
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- https://clinicaltrials.gov/ct2/show/NCT02629627
- https://www.ncbi.nlm.nih.gov/pubmed/28071044