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[Guadalajara] Association of Tacrolimus Trough Levels with Acute Renal dysfunction in Renal Transplant Patients
Universidad de Guadalajara
Vascular mechanics department, Institute of clinical and experimental therapeutics (INTEC), Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara. Guadalajara Jalisco, Mexico
Prof. Dr. SNI1 Fernando Grover Paez
Patricia Quezada Fernandez
English and Spanish
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Tacrolimus is an immunosuppressant widely used to prevent kidney transplant rejection. It has a very narrow range of safety and therapeutic effectiveness. Inadequate doses or levels of tacrolimus may result in graft rejection. High serum levels of tacrolimus are associated with multiple adverse effects with nephrotoxicity. The clinical response to therapy with this drug can not be completely correlated with the dose administered. The most effective way is to monitor tacrolimus concentrations in whole blood. One of the main determinants of these differences is the CYP3A5 gene polymorphism, which determines that about 80% of Caucasians are slow metabolizers and require lower doses than fast metabolizers. With the result of the investigation, it is sought to determine the relationship of serum levels of Tacrolimus to episodes of acute graft dysfunction confirmed by biopsy in our population,
What is the aim of the project?
To find the relationship between serum levels of Tacrolimus and acute graft dysfunction in renal transplant patients of the nephrology department of the Centro Medico Nacional de Occidente
What techniques and methods are used?
The clinical findings and laboratory test include cuantification of Tacrolimus concentration in whole blood, deetermination and recording of the variables: Acute graft dysfunction Tacrolimus serum level Age Gender Time from transplant Dosage / day of Tacrolimus Number of shots / day of Tacrolimus Donor / recipient compatibility Living / cadaveric donor graft during a interview with the patients
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Written report for the end of the exchange
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Previous research incursion is desirable but not limiting. Basic knowledge of Pharmacology and research. Disclosure limitations of a double-blind trial
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Israni; A. K.; Riad; S. M.; Leduc; R.; Oetting; W. S.; Guan; W.; Schladt; D.; ... & Jacobson; P. A. (2013). Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics. Transplant International; 26(10); 982-989.
- Tinti; F.; Meçule; A.; Poli; L.; Bachetoni; A.; Umbro; I.; Brunini; F.; ... & Mitterhofer; A. P. (2010; December). Improvement of graft function after conversion to once daily tacrolimus of stable kidney transplant patients. In Transplantation proceedings (Vol. 42; No. 10; pp. 4047-4048). Elsevier.
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