Projects
Name
Investigation of Breast Cancer Stem Cells Properties and Their Hormonal Profile
University
Egypt (IFMSA-Egypt) - Assiut University, Assiut
Domain
Oncology
Departement
South Egypt Oncology Institute, City Street, Assiut city, Assiut, Egypt.
Head
Prof. Dr. Mostafa El-Sharkawii
Tutor
Dr. Tarek Elsaba Dr. Hussein Fakhry Dr. Noha Ahmed Dr. Mahmoud Fahmy
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes No No No No Yes Yes Yes No No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Breast cancer is the most common cancer affecting women. The great majority of breast cancers are hormonal dependent on the sex steroid hormones, estrogen and progesterone. The anti-estrogen therapies including aromatase inhibitors are the current gold standard hormonal treatment for breast cancer and are being investigated for long-term prevention of breast cancer. Meanwhile, cancer stem cells have been isolated from breast cancer and progression to advanced metastatic stages. There is accumulating evidence that breast stem cells are involved in the hormonal sensitivity of breast cancer and they or their progenitors are expressing estrogen and progesterone receptors.
What is the aim of the project?
This study aims to identify and isolate breast cancer stem cells and study their hormonal profile and interaction
What techniques and methods are used?
1-Specimen Taking and examination after Mastectomy. 2- Isolation of Stem cells. 3- Tumor Markers Detection.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student is expected to participate actively in “Sample taking, Clinical examination, Data analysis & Results comprehension”: sample taking and clinical examination are expected to be observed first then done under supervision of the Professor, while data analysis and results comprehension are expected to be done under supervision of the professor first, then done on the student’s own, and the professor will review and discuss the results with them at the end.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Lectures conecring the topic & presentation of the clinical skills used.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It's prefered if the student have studied Oncology.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
- Kamangar; F.; G.M. Dores; and W.F. Anderson; Patterns of Cancer Incidence; Mortality; and Prevalence Across Five Continents: defining priorities to reduce cancer disparities in different geographic regions of the world. Journal of clinical oncology; 2006. 24(14): p.2137-2150
- Hamilton; R. and S. Kopin; Theory Development from studies with young women with breast cancer who are BRCA mutation negative. Advances in nursing science; 2013. 36(2): p. E41-E53 10.1097/ANS.0b013e3182901ff1
- Beatson; G.; On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment; with illustrative cases.1. The Lancet; 1896. 148(3802): p. 104-107
- Laroche; F.; et al.; classification of and risk factors for estrogen deprivation pain syndromes related to aromatase inhibitor treatments in women with breast cancer: A prospective Multicenter Cohort study. The journal of Pain; 2014. 15(3): p. 293-303
- Liehr; J.G.; is Estradiol a Genotoxic Mutagenic Carcinogen? Endocrine reviews; 2000. 21(1): p. 40-54
- Kuhl; H.; Breast cancer risk in the WHI study: The problem of obesity. Maturitas; 2005. 51(1): p. 83-97
- Hagan Cr Fau ? Lange; C.A. Lange; Molecular determinants of context- dependent progesterone receptor action in breast cancer. (1741-7015) (electronic).