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TCF7L2, FTO genetic variants in type II diabetes of Upper Egypt population. (Assuit University)
Egypt (IFMSA-Egypt) - Assiut University, Assiut
Department of Medical biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Prof. Dr. Abdel-Rahim Mohamed Abdel-Hafiz Maeki Ayed
Dr. Ayat Sayed
Type of Research Project
- Basic science
What is the background of the project?
Type II diabetes is a common health problem. The etiology of which is complex, and including many pathophysiological aspects. Type II diabetes is defined as a complex genetic disorder, with multiple genetic factors and environmental conditions interacting with each other. Currently about 30 genes carry genetic Polymorphisms implicated as genetic risk factors of T2D. Of these genes, TCF7L2 and FTO genes carry multiple single nucleotide polymorphisms (SNPs)that found to be T2D risk variants in many populations world-wide. To the best of our knowledge these genetic risk factors are not investigated in population of Upper Egypt.
What is the aim of the project?
The current study is set to investigate TCF7L2 and FTO SNPs as diabetes risk factors in upper Egyptian population using PCR based genotyping.
What techniques and methods are used?
This study includes DNA extraction, MS-PCR detection of antigens, Agarose gel electrophoresis, and candidate gene association study related statistical methods.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
The student will actively participate in DNA extraction, MS-PCR detection of antigens, Agarose gel electrophoresis, and candidate gene association study related statistical methods, data analysis and results comprehension are expected to be done under supervision of the professor first, then done on the student’s own, and the professor will review and discuss the results with them at the end.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Single introductory lecture at the start of the project to provide basics of T2D genetic and PCR technique.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student will prepare a poster - The student will prepare a presentation - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It's prefered if the student have studied Medical Biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Qi; Q. and F.B. Hu; Genetics of Type 2 Diabetes in European Populations. Journal of diabetes; 2012. 4(3): p. 203-212.
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