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Radium-223 for Metastatic Prostate Cancer. An attempt to see beyond what is known
Portugal (PorMSIC) - University of Coimbra, Coimbra
Biophysics Institute, Faculty of Medicine, University of Coimbra
Maria Filomena Botelho
Ana Margarida Abrantes and Ana Salome Pires
Type of Research Project
- Basic science
What is the background of the project?
Radium-223 is a radioactive element that localizes in bone. For men whose advanced prostate cancer consists almost exclusively of extensive bone metastases, treatment with radium-223 may be effective at relieving bone pain, preventing complications (broken bones, need for radiation therapy), and prolonging life. There is a relative lack of information concerning molecular pathways responsible for the effects of Radium-223 in cells of astration-resistant prostate cancer (mCRPC).
What is the aim of the project?
This project aims to study the effects of Radium-223 in prostate cancer cell lines.
What techniques and methods are used?
Cell culture methodology, molecular biology techniques (western blot, Fluorescence studies, flow cytometry, spectrophotometry)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will have the opportunity to be involve in all the various techniques, such as cell culture, western blot, fluorescence studies, flow cytometry. First, all the techniques will be demonstrated, after the student will perform them under supervision. If we consider that the student has enough competence to practice it alone, he will be able to.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
In different schools there are curricular units related with radiation, so it would be useful to have a student with this know-how but is not mandatory.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Ther Adv Med Oncol.?2016 Jul;8(4):294-304. doi: 10.1177/1758834016640494. Epub 2016 Apr 25.
- From palliative therapy to prolongation of survival: (223)RaCl2 in the treatment of bone metastases. Liepe K ;Shinto A .
- Anticancer Res.2016 Nov;36(11):5719-5730. Radium-223: Insight and Perspectives in Bone- metastatic Castration- resistant Prostate Cancer. Buroni FE 1 ; Persico MG ; Pasi F ; Lodola L; Nano ; Aprile C.
- Radium-223 dichloride for the treatment of metastatic prostate cancer. Turner PG; O'Sullivan J. Expert Opin Pharmacother. 2014 Oct;15(14):2105-11. doi: 10.1517/14656566.2014.955016.
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