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The effect of maternal obesity prior to and during pregnancy on the structure of brain regions of adult offsprings
Denmark (IMCC) - Aarhus university, Aarhus
Translational Neuropsychiatry Unit (TNU), Department of Clinical Medicine
Prof. Gregers Wegener
Type of Research Project
- Basic science
What is the background of the project?
Excessive weight gain prior to and during pregnancy has been associated with dysmetabolic and neurodevelopmental effects in offspring. Furthermore, maternal obesity programs apetite regulators in hypothalamus and inflammatory markers in the hippocampus, resulting in mood disorders. Maternal obesity increases the risk of developing early-onset childhood obesity whis is highly correlated to metabolic syndrome, type 2 diabetes and depression in adulthood. Assumed the rise in childhood obesity, potential interventions such as lifestyle adjustments, exercise, weight loss are important startegies that need to be explored to reduce the risk of developing metabolic syndrome and mental health disorders.
What is the aim of the project?
The aim of this project is to investigate activated histopathological parameters in the various brain regions after maternal high-fat diet and the effect on adult offspring brain to contribute to novel treatments and healthy lifestyle recommendations for future generations. In this study we use a model of maternal obesity to program offspring neurodevelopmental disorder.
What techniques and methods are used?
Offspring brains were immersed in paraformaldehyde 4%, and by applying various immunohistological protocols and stereological methods (three-dimensional investigation of two-dimensional biological tissues) the histopathological alteration of various brain regions will be examined.
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be introduced and trained to work with various techniques and software supposed to be applied in this project including newCAST software - Imaris imaging software and applying stereological methods under light microscopy - immunohistochemistry and afterward they have to do practice.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
None (can all be taught on-site)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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