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Identification of Innate Lymphoid Cell-2 in Allergenic Tissue
Thailand (IFMSA-Thailand) - Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok
Assoc. Prof. Anchalee Tungtrongchitr
Prof. Wanpen Chaicumpa, Assoc. Prof. Nitat Sookrung, Dr. Surasak Jittavisutthikul, Mr.Watee Seesuay
Type of Research Project
- Basic science
What is the background of the project?
Conventional mechanism of allergy is established based on the interaction between Immunoglobulin E (IgE) production, eosinophillia and activation of mast cell and type 2 helper T cell (TH2) after exposure to allergens. Main mediators in this reaction are TH2 cytokines including many Interleukins. Innate Lymphoid Cell-2 (ILC2) is a new population found in respiratory and gastrointestinal tissue and skin. The role of ILC2 in allergy was found according to the detection of TH2 cytokines expression. The goal of the project is to study the mechanism of allergy and identification of ILC2 in processed mouse tissue. Analysis of ILC2 and other immune cell location and distribution may lead to the understanding of underlying mechanisms as well as the application of novel allergic-vaccine-treatment to mouse models. Techniques used are mouse tissue processing and Immunohistochemistry.
What is the aim of the project?
The goal of the project is to process mouse tissue section and identification of innate lymphoid cell-2 (ILC2) for studying allergy mechanism and allergic-vaccine-treatment outcome. Analysis of ILC2 and other immune cell location and distribution may reveal some evidence supporting the role of ILC2 in allergy and underlying mechanism. In addition, applying a novel allergic-vaccine-treatment to mouse model can also point out the change in response to allergen.
What techniques and methods are used?
- Mouse tissue processing for tissue section - Immunohistochemistry
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will be responsible in Laboratory assistance. During that period, student will observe his or her tutor (s) on how to perform basic experiment and take this time to adapt to new working environment. After 1-2 weeks, the student will have a chance to fully participate in parts of the project by designing and conducting experiments under the supervisions of the tutor(s).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Laboratory skills: Immunohistochemistry (specimen processing, staining, imaging). Knowledge in mouse allergy model and allergy vaccine. The student must already pass a class in basic knowledge of Immunology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Meechan P; Tungtrongchitr A; Chaisri U; et al. Intranasal; liposome-adjuvanted cockroach allergy vaccines made of refined major allergen and whole-body extract of Periplaneta americana. Int Arch Allergy Immunol. 2013;161 (4):351-62.
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