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Innate Immunity to Infectious Disease
Thailand (IFMSA-Thailand) - Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok
Prof. Dr. Tararaj Dharakul
Assoc. Prof. Dr. Pattama Ekpo
Type of Research Project
- Basic science
What is the background of the project?
Innate immune responses against pathogens through pattern recognition receptors (PRRs), including Toll-like receptor (TLRs), NOD-like receptors (NLRs) and others such as retinoic acid inducible protein-1 (RIG1), melanoma differentiation associated protein 5 (MDA5). These receptors recognize conserved pathogen associated molecular patterns (PAMPs), induce inflammation and promote adaptive immune responses. The aim of the project is to investigate the roles of innate immunity in tropical infectious agents such as Leptospira spp. and Orientia tsutsugamushi, etc. Leptospirosis and Scrub Typhus are common acute febrile illness diseases in Thailand. The knowledge of host immune response will provide better understanding of the protection, prevention, and immunopathogenesis of these diseases. Techniques used include: cell culture, Reverse transcription polymerase chain reaction (qRT-PCR), conventional PCR, Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Western blot, and Enzyme-linked immunosorbent assay (ELISA).
What is the aim of the project?
The aim of the project is to investigate the roles of innate immunity in tropical infectious agents such as Leptospira spp and Orientia tsutsugamushi, etc. Scrub typhus and Leptospirosis are the common acute febrile illness disease in Thailand. The knowledge of host immune response will provide better understanding of the protection, prevention, and immunopathogenesis of these diseases.
What techniques and methods are used?
Cell culture Reverse transcription polymerase chain reaction (qRT-PCR), conventional PCR Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot Enzyme-linked immunosorbent assay (ELISA)
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student is responsible to some laboratory duties such as daily or weekly routine checking and maintenance of some instruments. As a researcher, student should take part in keeping a laboratory facility in good condition because all machines and safety equipment are necessary for the experiment. The student may also join in academic activities like lab meeting, journal club, seminar, and other cultural activities. During that period, student will observe his or her tutor on how to perform basic experiment then the student will have a chance to take a responsibility in some part of the project the supervisions of the tutor.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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