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How do bacteria protect their envelope: opening the ways to the design of new antibiotics
Belgium (BeMSA) - Université Catholique de Louvain, Brussels
Microbiology, de Duve Institute, Université catholique de Louvain, Brussels
Type of Research Project
- Basic science
What is the background of the project?
Gram-negative bacteria assemble a complex cell envelope. A variety of systems monitor envelope integrity and make sure to respond to damages in a fast and adequate manner. Our long-term goal is to discover and dissect the mechanisms that allow bacteria to protect their cell envelope. Our research will open the way to the design of new antibiotics.
What is the aim of the project?
The aim of the project is to dissect at the molecular level a stress sensing system allowing enterobacteria, including Escherichia coli, to detect damages occurring in the outer part of their envelope.
What techniques and methods are used?
Molecular biology techniques (cloning, Polymerization Chain Reaction, …), protein purification, protein expression, bacterial genetics, structural biology
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Motivation, some lab experience or experiencce in molecular biology (PCR, …) is a plus.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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