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To explore the role of Runx1 in the biological functions of Clara cells and in the Clara cell involved lung diseases
Taiwan (FMS-Taiwan) - Fu Jen University, Taipei
School of Medicine, Fu Jen Catholic University,
Professor Dee Pei
Associated Professor Chih-Li Chen
Type of Research Project
- Basic science
What is the background of the project?
Description: The biological functions of Clara cells in lung have been extensively studied. However, the molecular mechanisms involved in the regulation of biological function of Clara cells remains to be clarified. Our preliminary results revealed the expression of Runx1 in the lung through the embryo stage to adulthood in mice. We have established transgenic mice, Scgb1a1-cre/ERT2:Runx1L/L in which we can selectively disrupt the function of Runx1 in Clara cells under the treatment with Tomaxifen. Using this double transgenic animal model, our data indicated that disruption of Runx1 in Clara cells exacerbated ovalbumin induced asthma. Taken together, we reason that Runx1 play a vital role in the regulation of biological function of Clara cells and in the Clara cells involved lung diseases.
What is the aim of the project?
Aim: Aim 1: we will investigate explore the role of Runx1 in the biological function of Clara cells. We will establish primary Clara cell culture and explore the effects of Runx1 deficiency on the biological function of Clara cells. Aim 2: We will explore the role of Runx1 in Clara cell involved lung diseases including asthma, lung injury and lung fibrosis.
What techniques and methods are used?
Used Techniques: Cell culture, immunohistochemistry, western blotting, Enzyme-Linked ImmunoSorbent Assay (ELISA) animal care and animal model of lung diseases.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Skills with cell culture, SDS-PAGE, western blotting, total lysate extraction are preferred but not necessary.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
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