Projects
Name
Disorders related to the intake of gluten. Biochemical and Molecular Markers
University
Universidad Nacional de Tucuman
Domain
Gastroenterology
Departement
Institute of Applied Biochemistry.Faculty of Biochemistry, Chemistry and Pharmacy.National University of Tucuman.
Head
Carmen Rosa Araujo
Tutor
- Mar
Languages
Spanish (very important) - English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No No Yes Yes No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In 2012 the Experts Consensus described different disorders related to the gluten intake: Celiac disease, non-celiac Gluten Sensitivity and Gluten Allergy. From that moment on, it is a true challenge in the clinical practice to be able to find biochemical and molecular markers that allow performing a differential diagnosis. The different clinical presentations and manifestations that lead to malabsorptionprocesses that are related to other autoimmune diseases, that cause allergic reactions expand the search to the different organs and systems. The interdisciplinary work, that includes doctors in medicine, nutritionists and biochemists, pretends to establish an algorithm for differential diagnosis for the aforementioned disorders, according to the high or low probability to suffer them. - To improve the life quality of patients suffering from disorders related to the gluten intake. - To study biochemical and molecular markers that can help differentiating between Celiac Disease and Non-celiac gluten sensibility. - To propose based on the suspected population under study, the best diagnosis algorithm to be used in clinical practice. - Systematic review of current relevant bibliography. - Internships in gastroenterology and clinical medical practices to deepen the current knowledge of the disorders related to gluten. - Blood Sample Collection, with the previous informed consent of the patients suspected to have the disorder. - Detection of serological, molecular and cellular markers that allow the development of an algorithm for the differential diagnosis of disorders related to gluten. With this purpose the techniques to be used will include ELISA, Immunofluorescence, Flow cytometry and Molecular Biology.
What is the aim of the project?
- To improve the life quality of patients suffering from disorders related to the gluten intake. - To study biochemical and molecular markers that can help differentiating between Celiac Disease and Non-celiac gluten sensibility. - To propose based on the suspected population under study, the best diagnosis algorithm to be used in clinical practice.
What techniques and methods are used?
- Systematic review of current relevant bibliography. - Internships in gastroenterology and clinical medical practices to deepen the current knowledge of the disorders related to gluten. - Blood Sample Collection, with the previous informed consent of the patients suspected to have the disorder. - Detection of serological, molecular and cellular markers that allow the development of an algorithm for the differential diagnosis of disorders related to gluten. With this purpose the techniques to be used will include ELISA, Immunofluorescence, Flow cytometry and Molecular Biology.
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
- During the research exchange it is expected from the student: commitment, honesty and responsibility in the assigned work under the supervision of the tutor. - The student within the working group will have contact with the patients, will do a rotation by the biochemical laboratory and pathology.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
- Lectures and seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- The student must be graduated in Health Sciences (Medicine, Biochemistry, Clinical Analysis or similar). The student must have received their degree no more than 6 (six) months prior to the beginning of the project. - The student must have passed Gastroenterology or medical clinic.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles