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The role of the immune system in heart failure (HF)
Germany (bvmd) - Universitaet zu Koeln, Cologne
Cluster for Inflammation and Redox-Signaling, UKK, Kerpener Str. 62, 50937 Koeln, Germany
Prof. Dr. Stephan Baldus
Dr. Martin Mollenhauer
Type of Research Project
- Basic science
What is the background of the project?
Heart failure (HF) is the leading course of death in western countries and therapeutic options remain sparse. In this project the role of the leucouyte derieved enzyme myeloperoxidase (MPO) shall be investigated as a potentive target in HF therapy. MPO catalyzes the production of cytotoxic and reactive oxygen radicals, which are a destructive agent in vascular homeostasis. There was evidence that MPO is associated with the formation of endothelia dysfunction, acute coronary events and the formation of atrial fibrillation.
What is the aim of the project?
What is the aim of the project? The target of our project is the investigation of role and function of the MPO in HF and the evaluation of MPO inhibition in different musine HF models. We are trying to characterize the mechanism how MPO and other leucocytary systems are afflicting the vascular, cardiomyocytary and leucoytary integrity. The aim of our project is finding new options in the therapy of cardiovascular diseases.
What techniques and methods are used?
Techniques: Immunhistochemistry, Immunoblothing, aRT-PCR (realtime-polymerase chain reaction), ELISA (enzyme linked Immunosorbent assay), Echocardiography, Organbath for vessel function
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
None. Some laboratory experience is recommended but not required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
- Myeloperoxidase: A Leukocyte-Derived Protagonist of Inflammation and Cardiovascular Disease. Nussbaum C; Klinke A et al.; Antioxid Redox Signal. 2012 Oct 3.
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