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The genomic basis of immunological responses in prostate and kidney cancer
Germany (bvmd) - Ruprecht-Karls-Universitaet, Heidelberg
Section of Molecular Urooncology, Department of Urology, University of Heidelberg, Im Neuenheimer Feld 517, 69120 Heidelberg
Prof. Dr. Stefan Duensing
Prof. Dr. Stefan Duensing
Type of Research Project
- Basic science
What is the background of the project?
Cancer cells are frequently attacked by immune cells and macrophages. This has been exploited in the clinic by developing immunotherapies, most recently immune checkpoint inhibitors that lead to long lasting responses in a subset of patients. It is not known in detail what genomic factors of cancer cells are contributing to the extent and composition of immune cell infiltrates in malignant tumors. Such knowledge, however, will be instrumental for improving current immunotherapies as well as patient stratification.
What is the aim of the project?
The aim of the project is to morphologically characterize the number and the type of tumorinfiltrating immune cells and macrophages and correlate the results to certain mutations found in the respective tumor. Tumor for which either whole exome sequencing data or panel sequencing data have been obtained will be used. These data are already there and completely analyzed and validated by bioinformaticians.
What techniques and methods are used?
The incoming student will use immunohistochemical staining techniques on the tumor tissue together with light microscopy and digital image analysis to characterize infiltrating immune cells. A correlation with the gene mutations will be performed using basic statistical methods
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Spatial niche formation but not malignant progression is a driving force for intratumoral heterogeneity. Nature Commun. 2016 Jun 13;7:ncomms11845. doi: 10.1038/ncomms11845.
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